Active and Nonlinear Models for Cochlear Mechanics

耳蜗力学的主动和非线性模型

• 批准号: 7174705
• 负责人: Karl Grosh
• 金额: $ 21.32万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-05-01 至 2011-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7174705
• 关键词: Action Potentials; Applications Grants; Basilar Membrane; Binding; Cells; Cochlea; Collaborations; Coupling; Development; Electric Conductivity; Environment; Event; Future; Hair; Hair Cells; Health; Health Sciences; Hearing; In Vitro; Inner Hair Cells; Intercellular Fluid; Liquid substance; Measurement; Mechanics; Michigan; Modeling; Non-linear Models; Oregon; Organ of Corti; Outer Hair Cells; Pathway interactions; Physiological; Potential Energy; Preparation; Process; Prosthesis; Rate; Research; Research Institute; Research Personnel; Rest; Stereocilium; Test Result; Testing; Universities; Work; base; cell motility; in vivo; insight; mathematical model; model development; neuronal cell body; novel; novel strategies; relating to nervous system; research study; response; stem; tectorial membrane; tool

DESCRIPTION (provided by applicant): In the cochlea, acoustical, mechanical and electrical phenomena interact in a carefully coordinated fashion to filter incoming acoustical energy and convert it to neural input. We seek to develop a hierarchy of mechano- electrical-acoustical (MEA) mathematical models that predict the activity and nonlinearity seen in the healthy cochlea. The MEA models include the coupling of the cochlear electric pathways (through the scalae and organ of Corti circuitry) with the outer hair cells (OHCs) and a hydromechanical model for the cochlea. In this grant application, the development of these models is tied to the testing of the following three hypotheses of cycle-by-cycle active processes for cochlear activity: Hypothesis 1 is based solely on somatic OHC motility; Hypothesis 2 solely on OHC hair bundle (stereocilia) motility and Hypothesis 3 on a combination of OHC somatic and hair bundle motility. Novel tests of these hypotheses using combined electrical and acoustical excitation will be used to determine their validity. We will relate predictions to physiological experimental results and test hypotheses of cochlear activity in collaboration with two experimental groups, at the Oregon Hearing Research Center at Oregon Health and Science University and at the Kresge Hearing Research Institute at the University of Michigan. The ability to predict the response of the cochlea to electrical and mechanical (acoustical) inputs will assist in the development of noninvasive tools for assessing the health of hearing. Such models will also provide an insight into hearing protection by determining mechanisms of damage, and provide guidance in the development of future prosthetic devices.

描述（由申请人提供）：在耳蜗中，声学、机械和电学现象以仔细协调的方式相互作用，以过滤传入的声能并将其转换为神经输入。我们试图开发一个层次的机电声（MEA）数学模型，预测的活动和非线性健康耳蜗。MEA模型包括耳蜗电通路（通过耳蜗外毛细胞（OHC）和耳蜗的流体力学模型）的耦合（通过耳蜗的耳蜗电通路和Corti电路）。在这项资助申请中，这些模型的开发与以下三个假设的测试有关：假设1仅基于体细胞OHC运动;假设2仅基于OHC毛束（静纤毛）运动;假设3基于OHC体细胞和毛束运动的组合。新的测试，这些假设使用组合的电和声激励将被用来确定其有效性。我们将与两个实验小组合作，将预测与生理实验结果联系起来，并测试耳蜗活动的假设，这两个实验小组分别位于俄勒冈州健康与科学大学的俄勒冈州听力研究中心和密歇根大学的克雷斯吉听力研究所。预测耳蜗对电和机械（声学）输入的反应的能力将有助于开发用于评估听力健康的非侵入性工具。这些模型还将通过确定损伤机制来深入了解听力保护，并为未来假体设备的开发提供指导。