The Metabolic Syndrome in Mexican American Children

墨西哥裔美国儿童的代谢综合症

基本信息

批准号：
7189139
负责人：
RAVINDRANATH DUGGIRALA
金额：
$ 53.39万
依托单位：
TEXAS BIOMEDICAL RESEARCH INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-03-01 至 2010-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7189139
关键词：
Acanthosis Nigricans Adolescent Adult Age Biological Markers Birth Weight Candidate Disease Gene Carotid Arteries Child Childhood Cholesterol Complex Condition Coronary heart disease Data Diabetes Mellitus Dietary intake Disease Disease Marker Dyslipidemias Education Energy Metabolism Environmental Risk Factor Epidemic Etiology Factor Analysis Family Family Study Family history of General Population Genes Genetic Genetic Markers Genomics Goals Heart Hispanics Hyperinsulinism Hypertension Impaired fasting glycaemia Individual Inflammation Insulin Insulin Resistance Life Lipids Liver diseases Localized Measures Medial Medical History Metabolic Metabolic syndrome Mexican Americans Microalbuminuria Minority Minority Groups Non-Insulin-Dependent Diabetes Mellitus Obesity Obesity associated disease Overweight Participant Pattern Phenotype Physical activity Population Predisposition Prevalence Principal Investigator Public Health Purpose Questionnaires Rate Rest Risk Single Nucleotide Polymorphism Sum Television Thick United States Veterans Western World aged analytical tool base cohort design diabetic fitness genetic analysis genetic epidemiology genetic variant impaired glucose tolerance multidisciplinary non-alcoholic fatty liver prevent programs time use trait

项目摘要

DESCRIPTION (provided by applicant): As this RFA emphasizes, the prevalence rates of overweight/obesity, type 2 diabetes (T2DM), and the Metabolic Syndrome (MS: a constellation of metabolic abnormalities such as obesity and impaired glucose tolerance) have been increasing at epidemic proportions, particularly in minority groups such as Mexican Americans. However, the mechanisms that underlie the MS in children are unclear, and it is also not clear whether or not the precursors of the MS in children are the same as those in adults. If so, attempts to establish the precursors of the MS in children as well as to develop biomarkers and/or genetic markers that could help identify children at risk for the MS later in life, are of the utmost importance in developing effective strategies to prevent or treat children that are at high risk for the MS. The purpose of this proposal is to establish the precursors of the MS in Mexican American Children. Given that family history of T2DM is an important factor associated with the MS risk, plans to establish the precursors of the MS in children could be greatly advanced by examining the children of previously established adult family-based cohorts such as ours that are enriched with prediabetic and diabetic individuals. Added advantages of our design include the readily available MS-related data in adults, and already localized genomic regions that harbor the MS genes. In this context, we plan to examine 750 children (aged 6-17 years) of the adults representing distinct families in our ongoing San Antonio Family Birth Weight Study, who are the original participants of the three well-established Mexican American family studies, to establish the precursors of MS. The major goals of this project are: 1) to examine 750 children (aged 6-17) years of the adults representing various families in our ongoing San Antonio Birth Weight Study in order to measure various MS-related phenotypes (e.g., obesity, impaired glucose tolerance, dyslipidemia, and hypertension) and environmental factors such as physical activity and fitness; 2) to compare the MS risk profiles of the children to those already established in the adults of our family studies to verify whether or not the etiological mechanisms underlying the MS are different between children and adults using different analytical tools including the NCEP/ATPIII definition of the MS, factor analysis, and bivariate genetic analysis; and 3) to examine the association between MS phenotypes in children and 10 genetic markers (single nucleotide polymorphisms, SNPs) selected from each of 25 key positional and other candidate genes that we have identified, primarily from our ongoing linkage/association analyses, as potentially influencing MS phenotypes in adults. In sum, this study provides an unusual opportunity to contribute to a better understanding of the MS in Mexican Americans, both children and adults.