肺癌中的孢子-猫眼课题宝

肺癌中的孢子

批准号：

7284876

负责人：

BRUCE E. JOHNSON

金额：

$100.21万

依托单位：

DANA-FARBER CANCER INST

依托单位国家：

美国

项目类别：

财政年份：

2003

资助国家：

美国

项目状态：

已结题

起止时间：

2003-09-19 至 2008-06-30

来源：

https://reporter.nih.gov/project-details/7284876

关键词：

Angiogenesis Pathway Applications Grants Area Award Biological Biostatistics Core Boston Breast Budgets CCAAT-Enhancer-Binding Protein-alpha CDK2 gene CEBPA gene Cancer Center Cancer Patient Cancer cell line Cell Cycle Clinical Trials Communities Dana-Farber Cancer Institute Development Diagnostic Diagnostic Procedure Disease Drug Formulations Environmental Tobacco Smoke Equipment Evaluation Exposure to Financial Support Funding General Hospitals Generations Genetic Predisposition to Disease Genomics Goals Grant Health Hospitals Human In Vitro Incidence International Investigation K-Series Research Career Programs Lung Adenocarcinoma Malignant neoplasm of lung Malignant neoplasm of prostate Massachusetts Modeling Molecular Molecular Classification of Tumors Molecular Target Mus Non-Small-Cell Lung Carcinoma Nude Mice Nurses&apos Health Study Outcome Participant Pathogenesis Pathology Pathway interactions Patients Personal Satisfaction Physicians Play Population Population Control Population Sciences Process Prospective Studies Public Health Schools Research Research Infrastructure Research Personnel Resources Risk Role Smoking Staging Surrogate Endpoint Techniques Technology Testing Time Tissues Tobacco smoke Translations Tumor Suppressor Genes Universities Validation Vascular Endothelial Growth Factor Receptor Vascular Endothelial Growth Factor Receptor-2 Wages Woman angiogenesis base cancer cell career chemotherapy cohort cost design education planning experience in vivo inhibitor/antagonist leukemia medical schools men named group programs small molecule therapeutic target transcription factor translational study tumor

中文摘要

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英文摘要

DESCRIPTION (provided by applicant): This application creates a Specialized Program in Research Excellence (SPORE) in Lung Cancer at Harvard University within the Dana Farber/Harvard Cancer Center. The Dana-Farber/Harvard Cancer Center SPORE in Lung Cancer includes investigators from all Harvard-affiliated hospitals in Boston, Harvard Medical School, and the Harvard School of Public Health. This SPORE in Lung Cancer will build on the strengths of established ongoing investigation within the DF/HCC. Five major projects are supported: Project 1 will assess the impact of inherited susceptibility to adenocarcinoma of the lung in men and women and its interaction with exposures to tobacco smoke. Project 2 will analyze the dysregulation of C/EBP alpha in lung cancer, its downstream targets, and its potential impact on the outcome of lung cancer patients. Project 3 will apply array technology to the study of human lung cancer and its relationship to murine models. Project 4 will investigate the role of cdk2 inhibitors in vitro, in vivo, and apply these finding to human trials for patients with lung cancer. Project 4 will study the role of vascular endothelial growth factor receptor inhibitors and chemotherapy in vivo, and apply these finding to human trials for patients with lung cancer. These Projects are integrated by the establishment of 4 cores. These include 1) Tissue and Pathology Core, 2) Administration, Assessment and Planning Core, 3) Biostatistics Core, 4) Genomics Core. This SPORE application outlines a Developmental Projects Program that includes our plan for selection of new projects and includes seven submitted proposals that could be supported. The Career Developmental Award Program outlines the mechanism for the identification and support of talented young investigators in lung cancer. The Developmental Projects and Career Development Award Program will provide the focus for involvement of the community in planning and financial support of the DF/HCC Lung Cancer SPORE. The goal of the DF/HCC Lung Cancer SPORE is the translation of biological and technological advances into clinically meaningful advances for patients with lung cancer and subjects at risk for lung cancer.

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