A Wireless, Multi-Channel Telemetric Biosensor for Research in Animal Models

描述(由申请人提供)：现代医学依赖于动物模型，用于基础研究和新干预措施和药物的评估。在动物研究中，对各种生物学问题的生理学研究通常需要收集生物物理和生化参数。通常，最初的实验是在小哺乳动物中进行的，如小鼠或大鼠，新的范例涉及比较小鼠和大鼠的品系和亚品系，以确定变异的遗传来源。将传感器输出传输到外部环境的现有技术包括电线连接和束缚系绳，这限制了动物的移动和记录条件，或者涉及1-3个通道的固定集成无线系统，一次只能适用于一只动物。需要对生理变化随时间的变化进行研究，以评估疾病进展(或退化)或药物效应，此类研究最好在不受约束和未麻醉的啮齿动物中进行。目前的技术限制是芯片技术与多个可修改的传感器之间的接口。目前的连接器不能适应为睡眠、心率、体温等量身定做的位置，因此限制了实用性，增加了动物的使用，并将这项技术过度专业化到独特的地点。NanonComponent有限公司与凯斯西储大学合作，计划开发一种无线、多通道遥测生物传感器，用于研究可修正基因解剖的动物模型。该微系统是参数传感器与外部环境之间的接口。多通道表示最少4个输入通道，可以延伸到8个或更多通道。具体地说，将开发用于生物位、温度和压力的多通道无线遥测微系统。其他潜在的生化参数也将被考虑。将这些生物物理和生化参数集成到一个多通道无线遥测微系统中是本研究的最终目标。这项拟议的研究将促进动物研究，可能会导致更好地了解睡眠障碍和潜在的新干预措施。

DESCRIPTION (provided by applicant): Modern medical science is dependant upon animal models, for both basic research and evaluation of new interventions and drugs. Physiological investigation of various biological issues commonly requires the collection of biophysical and biochemical parameters in animal studies. Typically initial experiments are carried out in small mammals, such as a mouse or rat, and new paradigms involve the comparisons of strains and sub-strains of mice and rats to identify genetic sources of variability. Available techniques to transmit the sensor outputs to the external environment involve wire connections and restraint tethering, which limit animal movement and recording conditions, or involve fixed integrated wireless systems of 1-3 channels, applicable to only 1 animal at a time. Studies of physiologic variations over time are needed to assess disease progress (or regression) or drug effects, and such studies are preferably performed in the unrestrained and unanaesthetized rodent. The current limitation of technology is the interface between chip technology and multiple and modifiable sensors. Connectors at present cannot accommodate the tailored placements of recording for sleep, heart rate, temperature, etc, and thus limit utility, increase animal use, and overspecialize the technology to unique sites. Nanocomponent, Ltd., in partnership with Case Western Reserve University, proposes to develop a wireless, multi-channel telemetric biosensor for research in animal models amendable to genetic dissection. This microsystem is an interface between the parameter sensors and the external environment. The multi-channels means a minimum of 4 input channels and can extend to 8 or more channels. Specifically, multi-channel wireless telemetric microsystems for biopotentials, temperature, and pressure will be developed. Other potential biochemical parameters will be considered. Integration of these biophysical and biochemical parameters into a multi-channel wireless telemetric microsystem is the ultimate goal of this research. The proposed research will facilitate animal studies that may lead to a better understanding of sleep disorders and potentially new interventions.