Sleep Medicine Neurobiology and Epidemiology

 描述（由申请人提供）：该培训补助金在睡眠健康及其生理学和睡眠障碍的流行病学和治疗领域产生医生和博士后研究人员，这些睡眠障碍严重影响个人生活质量，并在我们的社会中产生导致行为和心血管疾病的疾病。在转化研究的许多层面上都需要基础发现和临床结果研究。传统上认为因果通路与肥胖、性别、衰老等有关，通过生理测试进行临床评估。因此，睡眠医学科学（睡眠生理学和昼夜节律）在对生物标志物、蛋白质网络和大脑生理学的功能理解方面仍存在重大差距，这将为未来的治疗和预防提供信息。一个障碍是缺乏跨翻译范围的研究者和受训者看到更广泛画面的能力-即临床医生认识到需要基本的 研究和那些在基础研究了解临床疾病或综合征。有明显的机会，以改善目前的治疗，通过比较有效性研究或新技术。该项目由凯斯西储大学睡眠障碍研究中心负责人金曼·P·斯特罗指导。该中心现在进入大学的三个学院（医学，工程和护理），并与四个克利夫兰学术医疗中心合作。他和他的两个副主任批准入学的程序和监测学员的进步使用形成，全面的评估工具。回顾和展望，该项目将转向流行病学和生理学的根源，但保留课程元素和硕士学位系统生物学和生物信息学以及临床研究学位。有一个核心的12名教师导师和4名早期职业教师作为“初级培训师”;和9名经验丰富的睡眠教师谁同意参加作为一个实习委员会的成员。列出的教师代表六个部门，每个部门都在睡眠，昼夜节律生物学，睡眠流行病学，呼吸控制和/或临床研究方面发表了论文。该计划要求两名研究生和两名博士前实习生。我们为MD博士后学员提供临床研究硕士学位（CTST临床研究学者计划）或系统生物学硕士学位的选择。对于所有学员的本质是个性化的，监督的研究培训;和所有学员见面，从事教学工作，包括睡眠科学和医学，接触其道德，法律的，和社区问题，和职业发展。对于博士预科生，学位授予部门决定课程工作，论文进度和毕业状态，至少有一个T32教师作为博士的成员。以马克思博士后学员还成立了一个培训委员会，评估他们的进展，并提供职业指导。所有受训人员都有一套工作，并对进展情况进行自我评估，作为半年期评估的基础。所有学员都必须参加睡眠大圆桌会议和诊所，以及该小组与外部顾问和教师的年度务虚会。一个强大的特点是医学，儿科学，生理学和生物物理学，神经科学，计算机科学和工程，生物统计学和流行病学之间的跨学科联系。该提案解决了研究人员更好地管理睡眠问题和障碍的需求，如睡眠呼吸暂停和失眠，这严重影响了美国和世界的公共健康。该方法涉及一个结构化的计划，其中研究生，医生-科学家和博士后研究员学习计划，进行和发表睡眠，其障碍及其与人类疾病的关系的研究。(End摘要）

 DESCRIPTION (provided by applicant): This training grant produces physician and post-doctoral investigators in the field of sleep health and its physiology and the epidemiology and treatment of sleep disorders that substantially impact individual quality-of-life and produce illnesses causing behavioral and cardiovascular morbidity in our society. There are needs for basic discovery and clinical outcomes research at many levels of translational research. Causal pathways are traditionally considered in the associations with obesity, gender, aging, etc., and clinical assessments though physiologic testing. As a result, science of sleep medicine (sleep physiology and circadian rhythm) still has major gaps in functional understanding of biologic markers, protein networks, and brain physiology which will inform future treatments and prevention. There One barrier is a paucity of investigators across the translational spectrum and the ability of trainees to see the broader picture- i.e. clinicians appreciating the need for basic research and those in fundamental research understanding the clinical disease or syndrome. There are evident opportunities to improve current therapy through comparison effectiveness studies or new technology. The program is directed by Kingman P. Strohl, who heads the Center for Sleep Disorders Research at Case Western Reserve University. This Center now reaches into three Schools in the University (Medicine, Engineering, and Nursing) and engages four Cleveland academic medical centers. He and his two Associate Directors approve admission to the program and monitor trainees' progress using formative, comprehensive assessment tools. Looking backwards and forwards, the program will move towards its roots in epidemiology and physiology, yet retain curricular element and M.S. degrees in Systems Biology and Bioinformatics, and Clinical Investigation. There is a core of twelve faculty mentors and four early career faculty as "junior trainers"; and nine experienced sleep faculty who agree to participate as a member of a trainee committee. Listed faculty represent six departments and each has published work in sleep, circadian biology, sleep epidemiology, respiratory control, and/or clinical investigation. The program requests two post-graduate, and two pre-doctoral trainees. We provide options for a Master's Degree in Clinical Investigation (the CTST Clinical Research Scholars Program) or in Systems Biology for MD post-doctoral trainees. For all trainees the essence is individualized, supervised research training; and all trainees meet to engage in didactic work encompassing sleep science and medicine, exposure to its ethical, legal, and community issues, and career development. For pre-doctoral trainees, the degree-granting department determines course work, thesis progress and graduation status, with at least one T32 faculty as a member of the Ph.D. committee. Post-doctoral trainees also create a training committee which assesses their progress, and provides career guidance. All trainees maintain a portfolio of work with self-assessments of progress that forms the basis for semi-annual assessments. Attendance at Sleep Grand Rounds and in the clinic is required for all mentees, and as is the annual retreat of the group with outside advisors and faculty. A strong feature is the interdisciplinary linkages among Medicine, Pediatrics, Physiology & Biophysics, Neuroscience, Computer Sciences and Engineering, and Biostatistics and Epidemiology. The proposal addresses the need for researchers to better manage sleep problems and disorders, like sleep apnea and insomnia, which significantly affect public health in the United States and the world. The methods involve a structured program in which graduate students, physician- scientists, and postdoctoral PhD fellows learn to plan, conduct, and publish research in sleep, its disorders, and its relationship to human illness. (End of Abstract)