Polymer Coatings for Prevention of Bacterial Contamination of Dental Waterlines

防止牙齿水线细菌污染的聚合物涂层在牙齿修复和外科手术过程中，大量的水用于冲洗和冷却。在临床牙科和牙科手术中，细菌污染输送这种水的牙科单位水线是一个持续存在的问题。虽然大多数健康患者的细菌感染风险很小，但由于疾病或药物治疗导致免疫系统受损的患者风险较高。此外，牙科保健专业人员长期暴露于牙科单位产生的受污染的水和气溶胶。现有的对抗细菌污染和生物膜形成的方法通常不能有效地将细菌数量减少到美国牙科协会推荐的水平。最后，大多数现有方法依赖于医护人员遵守特定的维护计划，如果不遵守这些计划，这些方法在很大程度上是无效的。牙科水线防污的新方法将显著减少或消除常规去污维护的需要，这是牙科保健界非常感兴趣的。防止细菌附着在牙齿水线和生物膜形成的表面涂层将大大减少这些健康风险。如果细菌不能附着在牙齿水线的表面，它们就不能形成生物膜，使它们无法大量繁殖并污染供水系统。涂料将被开发和评估，以防止细菌附着在通常用于制造牙科水线的材料表面。在第一阶段，将开发表面涂层，使其紧紧粘附在这些材料上，并形成覆盖这些表面的涂层。在第二阶段，将评估这些涂层表面在静态和动态条件下防止细菌附着在这些材料表面的能力。在未来的研究中，将对所开发的涂层在实际牙单元水线上的效果进行评估。项目摘要/摘要（描述）第7页首席研究员/项目主管（后、中、前）：Dalsin, Jeffrey， L。

Polymer Coatings for Prevention of Bacterial Contamination in Dental Waterlines Copious amounts of water are used for rinsing and cooling purposes in restorative and surgical dental procedures. Bacterial fouling of dental unit waterlines that deliver this water is a persistent problem in clinical dentistry and dental surgery. While the risk of bacterial infection is slight in most healthy patients, those patients with compromised immune systems due to disease or drug therapy are at elevated risk. Additionally, dental healthcare professionals are subjected to chronic exposure to contaminated water and aerosols generated from the dental unit. Existing approaches to combat bacterial contamination and biofilm formation are typically not effective in reducing bacteria counts to levels recommended by the American Dental Association. Finally, the majority of the existing approaches rely on healthcare workers to adhere to specific maintenance schedules that, if not followed, render the approaches largely ineffective. New approaches to dental waterline antifouling that would significantly reduce or eliminate the need for routine decontamination maintenance are of great interest to the dental healthcare community. Surface coatings which repel bacterial attachment on dental waterlines and biofilm formation would significantly reduce these health risks. If bacteria cannot attach to the surfaces of dental waterlines, they will not be able to form biofilms to allow them to reproduce in large numbers and contaminate the water supply. Coatings will be developed and evaluated that prevent bacterial attachment to surfaces of materials commonly used in the manufacture of dental waterlines. In stage 1, surface coatings will be developed that adhere tightly to these materials and form coatings covering these surfaces. In stage 2, these coated surfaces will be evaluated for their ability to prevent bacterial attachment to the surfaces of these materials under both static and dynamic conditions. In future research, the coatings that have been developed will be evaluated for their effective on actual dental unit waterlines. Project Summary/Abstract (Description) Page 7 Principal Investigator/Program Director (Last, first, middle): Dalsin, Jeffrey, L.