Noninvasive Diagnosis of Compartment Syndrome

筋膜室综合征的无创诊断

• 批准号: 7109746
• 负责人: JOHN E LYNCH
• 金额: $ 9.85万
• 依托单位: LUNA INNOVATIONS, INC.
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-01 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7109746
• 关键词: diagnosis; leg; measurement; muscle; noninvasive diagnosis; perfusion; syndrome; ultrasound

DESCRIPTION (provided by applicant): Inaccuracy in the current methods of compartment syndrome diagnosis often leads to delays in treatment. Missed diagnosis of compartment syndrome to be 1 of the most common causes of litigation against doctors in North America, with the average malpractice award from a missed compartment syndrome case approximately $280,000 in 1993. In the absence of good diagnostic tools for compartment syndrome, anecdotal evidence suggests that the fasciotomy, a surgical opening of the muscle fascia to release compartment pressures is often performed prophylactically, subjecting the patient to a long and expensive recovery that might otherwise be avoided. The aim of this Phase I SBIR is to investigate whether the enhanced capabilities of Luna's Quantitative Ultrasound System (QUS) will result in improved correlation between an ultrasound-derived pressure factor and slit-catheter measurements of intramuscular pressure (IMP), the current gold standard measurement for diagnosing compartment syndrome. As part of this overall objective, we propose a series of modifications to Luna's QUS leading to a 1-month, 10-patient study at the UCSD Department of Orthopaedics in which IMP in the 4 compartments of the lower leg is temporarily raised through well-established models.

描述(由申请人提供)：目前间隔室综合征诊断方法的不准确经常导致治疗的延误。漏诊间隔症候群是北美最常见的针对医生的诉讼原因之一，1993年，一个遗漏间隔室综合症案例的平均医疗事故赔偿金约为28万美元。在对筋膜间室综合征缺乏良好的诊断工具的情况下，坊间证据表明，筋膜切开术是一种外科手术，通过打开肌肉筋膜来释放筋膜间室压力，通常是预防性的，使患者经历了漫长而昂贵的康复，否则可能会避免这种情况。这一阶段SBIR的目的是研究露娜的定量超声系统(QUS)能力的增强是否会导致超声派生压力因素与狭缝导管肌肉内压测量之间的相关性提高，狭缝导管肌肉内压是目前诊断筋膜间室综合征的金标准测量方法。作为这一总体目标的一部分，我们对露娜的QUS提出了一系列修改，导致在加州大学圣迭戈分校骨科进行了一项为期1个月、10名患者的研究，在该研究中，通过成熟的模型暂时提高了小腿4个间隙的IMP。

项目成果

New noninvasive ultrasound technique for monitoring perfusion pressure in a porcine model of acute compartment syndrome.

• DOI: 10.1097/bot.0b013e31819901db
• 发表时间: 2009-03
• 期刊: Journal of orthopaedic trauma
• 影响因子: 2.3
• 作者: Garabekyan T;Murphey GC;Macias BR;Lynch JE;Hargens AR
• 通讯作者: Hargens AR

Noninvasive monitoring of elevated intramuscular pressure in a model compartment syndrome via quantitative fascial motion.

• DOI: 10.1002/jor.20778
• 发表时间: 2009-04
• 期刊: JOURNAL OF ORTHOPAEDIC RESEARCH
• 影响因子: 2.8
• 作者: Lynch, John E.;Lynch, John K.;Cole, Steven L.;Carter, Jonathan A.;Hargens, Alan R.
• 通讯作者: Hargens, Alan R.