Noninvasive Diagnosis of Compartment Syndrome

描述（由申请人提供）：目前筋膜室综合征诊断方法的不准确性常常导致治疗延误。在北美，对筋膜间室综合征的漏诊是对医生提起诉讼的最常见原因之一，在1993年，一个筋膜间室综合征漏诊的平均医疗事故赔偿额约为28万美元。在缺乏良好的筋膜室综合征诊断工具的情况下，轶事证据表明，筋膜切开术（通过外科手术打开筋膜以释放筋膜室压力）通常是预防性的，这使患者经历了一段漫长而昂贵的康复期，否则这是可以避免的。该I期SBIR的目的是研究Luna定量超声系统（QUS）功能的增强是否会导致超声衍生压力因子与缝道导管肌内压（IMP）测量之间的相关性改善，IMP是目前诊断筋膜间室综合征的金标准测量。作为这一总体目标的一部分，我们对Luna的QUS进行了一系列修改，并在UCSD骨科进行了为期1个月、10名患者的研究，通过完善的模型暂时抬起下肢4个腔室的IMP。

DESCRIPTION (provided by applicant): Inaccuracy in the current methods of compartment syndrome diagnosis often leads to delays in treatment. Missed diagnosis of compartment syndrome to be 1 of the most common causes of litigation against doctors in North America, with the average malpractice award from a missed compartment syndrome case approximately $280,000 in 1993. In the absence of good diagnostic tools for compartment syndrome, anecdotal evidence suggests that the fasciotomy, a surgical opening of the muscle fascia to release compartment pressures is often performed prophylactically, subjecting the patient to a long and expensive recovery that might otherwise be avoided. The aim of this Phase I SBIR is to investigate whether the enhanced capabilities of Luna's Quantitative Ultrasound System (QUS) will result in improved correlation between an ultrasound-derived pressure factor and slit-catheter measurements of intramuscular pressure (IMP), the current gold standard measurement for diagnosing compartment syndrome. As part of this overall objective, we propose a series of modifications to Luna's QUS leading to a 1-month, 10-patient study at the UCSD Department of Orthopaedics in which IMP in the 4 compartments of the lower leg is temporarily raised through well-established models.