NOVEL ESOPHAGEAL MOTOR FUNCTION ASSESSMENT SYSTEM

新型食管运动功能评估系统

• 批准号: 7051858
• 负责人: Jianfeng Chen
• 金额: $ 10万
• 依托单位: MEDKINETIC, INC.
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-01 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7051858
• 关键词: Internet; biomedical automation; computer assisted diagnosis; computer program /software; computer system design /evaluation; computers; diagnosis design /evaluation; esophagogastric junction; esophagus motility /pressure; gastrointestinal disorder diagnosis

DESCRIPTION (provided by applicant): Functional gastrointestinal motility diseases are common and make up about 40% of all gastroenterology patients. Typical esophageal motor disorders include dysphasia, gastroesophageal reflux disease (GERD), non-cardiac chest pain, etc., however the effective diagnosis and treatment of these diseases are still a major challenge for clinical gastroenterology. At present the commercially available diagnosis systems are primitive and require users to have extensive operational experiences and profound specialized knowledges to interpret the data, which have greatly impeded the widespread use of such systems. The long-term goal of this project is to develop an interactive and automated esophageal motility assessment system. The system is designed to be interactive during the procedure and to provide an automated diagnosis of various motility disorders. These novel features will popularize the esophageal motility test and make it possible to be used by healthcare providers with little experience in esophageal motility. The phase I of the project is to prove the feasibility of such an assessment system with the following specific aims: Aim 1: Automated localization of the lower esophageal sphincter and interactive data acquisition; Aim 2: The removal of respiratory artifacts in the LES pressure recording; Aim 3: Data analysis and knowledge- based automated diagnosis; Aim 4: Development of the user friendly software platform. Software will be developed to test the feasibility of implementing these innovative features of the proposed system and will be tested and optimized using existing clinical data. A comprehensive team has been established with expertise in software programming, biomedical signal processing and clinical testing of esophageal motility. Relevance: Esophageal motility disorders are seen in about 40% of clinical gastroenterology patients. While commercial systems are currently available to identify these disorders, their widespread uses are hindered by the requirement of extensive knowledges on esophgeal motility. The automated diagnostic system to be developed in this project will solve this problem and popularize this important diagnostic method.

描述（申请人提供）：功能性胃肠动力疾病很常见，约占所有胃肠病患者的 40%。典型的食管运动障碍包括吞咽困难、胃食管反流病（GERD）、非心源性胸痛等，但这些疾病的有效诊断和治疗仍然是临床胃肠病学的一大挑战。目前商用的诊断系统比较简陋，需要用户具有丰富的操作经验和深厚的专业知识来解读数据，这极大地阻碍了此类系统的广泛使用。该项目的长期目标是开发交互式、自动化的食管运动评估系统。该系统设计为在手术过程中进行交互，并提供各种运动障碍的自动诊断。这些新颖的功能将普及食管运动测试，并使食管运动经验很少的医疗保健提供者可以使用它。该项目第一阶段是为了证明这样一个评估系统的可行性，具体目标如下： 目标1：食管下括约肌的自动定位和交互式数据采集；目标 2：消除 LES 压力记录中的呼吸伪影；目标3：数据分析和基于知识的自动化诊断；目标4：开发用户友好的软件平台。将开发软件来测试实施拟议系统的这些创新功能的可行性，并将使用现有的临床数据进行测试和优化。已经建立了一个综合团队，拥有软件编程、生物医学信号处理和食管运动临床测试方面的专业知识。相关性：约 40% 的临床胃肠病患者存在食管动力障碍。虽然目前可以使用商业系统来识别这些疾病，但由于需要对食管运动有广泛的了解，因此阻碍了它们的广泛使用。本项目将开发的自动化诊断系统将解决这一问题，并普及这一重要的诊断方法。