Non Invasive Tear Fluid Glucose Sensor Photonic Crystals

无创泪液葡萄糖传感器光子晶体

• 批准号: 7054998
• 负责人: GERALD G CANO
• 金额: $ 9.9万
• 依托单位: GLUCOSE SENSING TECHNOLOGIES, LLC
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-01 至 2007-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7054998
• 关键词: bioengineering /biomedical engineering; biomaterial development /preparation; blood glucose; colorimetry; contact lens; diagnosis design /evaluation; glucose tolerance test; noninvasive diagnosis; patient monitoring device; photonics; spectrometry; tear

DESCRIPTION (provided by applicant): This Phase I research and development program will develop novel, real-time, noninvasive (or minimally invasive) glucose colorimetric sensors for tear fluid. These sensors are based on new photonic crystal chemical sensing materials recently invented at the University of Pittsburgh. These photonic crystal sensors use arrays of nanosclae particles to diffract visible light. The wavelength of light diffracted and the color perceived visually can be used to determine the glucose concentration. This glucose sensing material will be utilized as the sensing element of a contact lens, as well as an ocular insert designed for use underneath the lower eyelid. The patients will determine their glucose concentration by utilizing the simple spectrometer device. The observed diffraction wavelength reports on the patient's tear fluid glucose concentration. Since the tear fluid glucose concentration tracks the blood glucose concentration, a tear fluid glucose measurement determines the blood glucose concentration. We will optimize the responsivity of these sensor materials and develop fabrication methods to incorporate the sensing material in contact lenses and ocular insert-type devices which will be tested in Phase II of this program in animals and humans. These minimally invasive tear fluid glucose sensors will revolutionize glycemic control for patients with diabetes mellitus. These devices will permit painless, continuous, inexpensive monitoring of glucose levels, which will dramatically increase patient glucose monitoring compliance and the long term health consequences of diabetes mellitus.

描述(申请人提供)：这个第一阶段的研究和开发计划将开发用于泪液的新型、实时、非侵入性(或微创)葡萄糖比色传感器。这些传感器是基于匹兹堡大学最近发明的新型光子晶体化学传感材料。这些光子晶体传感器使用纳米云母颗粒阵列来衍射可见光。衍射光的波长和视觉感知的颜色可以用来确定葡萄糖浓度。这种葡萄糖传感材料将被用作隐形眼镜的传感元件，以及设计用于下眼皮下的眼球植入件。患者将利用简单的光谱仪设备来测定他们的葡萄糖浓度。观察到的衍射波长反映了患者泪液中的葡萄糖浓度。因为泪液葡萄糖浓度跟踪血糖浓度，所以泪液葡萄糖测量确定血糖浓度。我们将优化这些传感器材料的响应性，并开发制造方法，将这些传感器材料整合到隐形眼镜和眼部嵌入型设备中，这些设备将在该计划的第二阶段在动物和人类身上进行测试。这些微创泪液葡萄糖传感器将彻底改变糖尿病患者的血糖控制。这些设备将允许对血糖水平进行无痛、持续、廉价的监测，这将极大地提高患者对血糖监测的遵从性，并降低糖尿病的长期健康后果。