University of Texas Specialized Program in Acute Stroke

德克萨斯大学急性中风专业项目

• 批准号: 7227990
• 负责人: JAMES C GROTTA
• 金额: $ 7.43万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-15 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7227990
• 关键词: clinical research; human subject; patient oriented research; stroke; stroke therapy

DESCRIPTION: (abstract provided by the applicant): The past 20 years of stroke research have shown that acute stroke is a treatable disease but reversibility of damage is tightly time dependent. It is possible to find exciting treatment strategies in the laboratory, but difficult to design and carry out clinical research to translate them into clinical benefit. Even when effective therapy is demonstrated, there are unexpectedly huge impediments to having it adopted and widely available. Given the massive public health problem of stroke in our aging population, these conundrums demand our attention. They are the foci of the UT Stroke Program and the SPOTRIAS PA. The thematic model of our Stroke Program is to develop improved treatment of acute stroke by 1) laboratory investigation into the biology of stroke, 2) clinical investigation of new therapies based on these laboratory studies, and 3) assessment of outcome and improved application of effective therapies. This Program Project has three broad Specific Aims: 1. Development of effective new acute stroke therapies through clinical research projects based on biological principles of ischemic injury learned in the laboratory. We will describe four planned Phase 1 or 2 Clinical trials of novel acute interventions; caffeinol for neuroprotection, the thrombin inhibitor argatroban to enhance reperfusion after TPA, ultrasound to augment clot lysis after TPA, and constraint induced movement therapy to amplify recovery. These projects require the multidisciplinary involvement of EMS, Emergency Medicine, Radiology, Critical Care, Ultrasound, and Rehabilitation. 2. Application of more efficient and widespread acute stroke treatment by improving the organization of local and regional stroke centers using cutting-edge telemedicine technology, and evaluation of a novel middle-school educational initiative to help solve the problem of inadequate public knowledge. 3. Development of Clinical, Statistical, Human Tissue, and Training "Cores" that will facilitate the accomplishment of Specific Aims # 1 and 2. These cores will also provide important new resources for fellowship training.

描述：(申请人提供摘要)： 过去20年的中风研究表明，急性中风是一种可以治疗的疾病，但 损伤的可逆性与时间密切相关。在实验室中找到令人兴奋的治疗策略是可能的，但很难设计和进行临床研究将其转化为临床益处。即使证明了有效的治疗方法，也存在着意想不到的巨大障碍，要让它被采用并广泛使用。鉴于中风在我们老龄化人口中的巨大公共卫生问题，这些难题需要我们关注。它们是UT卒中计划和SPOTRIAS PA的重点。我们中风计划的主题模式是通过1)对中风生物学的实验室调查，2)基于这些实验室研究的新疗法的临床研究，以及3)评估结果和改进有效疗法的应用，来开发改进的急性中风治疗方法。该计划项目有三个广泛的具体目标：1.根据实验室学到的缺血性损伤的生物学原理，通过临床研究项目开发有效的新的急性中风疗法。我们将介绍四个计划中的新急性干预措施的1期或2期临床试验：用于神经保护的咖啡因、用于增强TPA后再通的凝血酶抑制剂阿加曲班、用于增强TPA后的血栓溶解的超声波，以及用于增强恢复的强制诱导运动疗法。这些项目需要EMS、急诊医学、放射学、危重护理、超声波和康复等多学科的参与。 2.应用更有效和更广泛的急性卒中治疗，通过改善 利用尖端远程医疗技术组织地方和区域中风中心， 和评估一项新的中学教育倡议，以帮助解决 公众知识不足。3.开发临床、统计学、人体组织和培训“核心”，以促进实现具体目标1和2。这些核心还将为研究金培训提供重要的新资源。