Evaluating the combined effects of environmental pollutants on the evolution of antimicrobial resistance
评估环境污染物对抗菌素耐药性演变的综合影响
基本信息
- 批准号:2859345
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:英国
- 项目类别:Studentship
- 财政年份:2023
- 资助国家:英国
- 起止时间:2023 至 无数据
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
Project BackgroundAntimicrobial resistance (AMR) is one of the greatest threats to modern society. The environment is increasingly recognised as playing an important role in the evolution, emergence, and dissemination of AMR. Antibiotics enter the environment from a variety of sources, where they reside at low concentrations that have been shown to select for AMR. However, most research to date has only studied effects of single antibiotics, despite the fact antibiotics in the environment are found in complex mixtures with other pollutants that could co-select for AMR. Project Aims and MethodsA growing body of research has demonstrated that the minimal selective concentrations of antibiotics can be very low, similar to concentrations of antibiotics measured in the environment. Antibiotic pollution may therefore select for antimicrobial resistance in the environment. However, many other environmental pollutants exhibit antimicrobial activity, and these may also generate a selective pressure that favours resistant bacteria. This project will explore the potential mixture effects of antibiotics and other pollutants on the evolution of antimicrobial resistance. We encourage applicants to be actively involved in the design and direction of the research.
项目背景抗生素耐药性(AMR)是现代社会面临的最大威胁之一。人们越来越认识到环境在抗生素耐药性的演变、出现和传播中发挥着重要作用。抗生素从各种来源进入环境,它们以低浓度存在于环境中,已被证明会选择抗菌素耐药性。然而,迄今为止,大多数研究只研究了单一抗生素的影响,尽管环境中的抗生素与其他污染物存在复杂的混合物,可能共同选择抗生素耐药性。项目目标和方法越来越多的研究表明,抗生素的最小选择浓度可以非常低,与环境中测量的抗生素浓度相似。因此,抗生素污染可能选择环境中的抗菌素耐药性。然而,许多其他环境污染物表现出抗菌活性,这些也可能产生有利于耐药细菌的选择性压力。该项目将探索抗生素和其他污染物对抗菌素耐药性演变的潜在混合效应。我们鼓励申请人积极参与研究的设计和方向。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
其他文献
Internet-administered, low-intensity cognitive behavioral therapy for parents of children treated for cancer: A feasibility trial (ENGAGE).
针对癌症儿童父母的互联网管理、低强度认知行为疗法:可行性试验 (ENGAGE)。
- DOI:
10.1002/cam4.5377 - 发表时间:
2023-03 - 期刊:
- 影响因子:4
- 作者:
- 通讯作者:
Differences in child and adolescent exposure to unhealthy food and beverage advertising on television in a self-regulatory environment.
在自我监管的环境中,儿童和青少年在电视上接触不健康食品和饮料广告的情况存在差异。
- DOI:
10.1186/s12889-023-15027-w - 发表时间:
2023-03-23 - 期刊:
- 影响因子:4.5
- 作者:
- 通讯作者:
The association between rheumatoid arthritis and reduced estimated cardiorespiratory fitness is mediated by physical symptoms and negative emotions: a cross-sectional study.
类风湿性关节炎与估计心肺健康降低之间的关联是由身体症状和负面情绪介导的:一项横断面研究。
- DOI:
10.1007/s10067-023-06584-x - 发表时间:
2023-07 - 期刊:
- 影响因子:3.4
- 作者:
- 通讯作者:
ElasticBLAST: accelerating sequence search via cloud computing.
ElasticBLAST:通过云计算加速序列搜索。
- DOI:
10.1186/s12859-023-05245-9 - 发表时间:
2023-03-26 - 期刊:
- 影响因子:3
- 作者:
- 通讯作者:
Amplified EQCM-D detection of extracellular vesicles using 2D gold nanostructured arrays fabricated by block copolymer self-assembly.
使用通过嵌段共聚物自组装制造的 2D 金纳米结构阵列放大 EQCM-D 检测细胞外囊泡。
- DOI:
10.1039/d2nh00424k - 发表时间:
2023-03-27 - 期刊:
- 影响因子:9.7
- 作者:
- 通讯作者:
的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('', 18)}}的其他基金
An implantable biosensor microsystem for real-time measurement of circulating biomarkers
用于实时测量循环生物标志物的植入式生物传感器微系统
- 批准号:
2901954 - 财政年份:2028
- 资助金额:
-- - 项目类别:
Studentship
Exploiting the polysaccharide breakdown capacity of the human gut microbiome to develop environmentally sustainable dishwashing solutions
利用人类肠道微生物群的多糖分解能力来开发环境可持续的洗碗解决方案
- 批准号:
2896097 - 财政年份:2027
- 资助金额:
-- - 项目类别:
Studentship
A Robot that Swims Through Granular Materials
可以在颗粒材料中游动的机器人
- 批准号:
2780268 - 财政年份:2027
- 资助金额:
-- - 项目类别:
Studentship
Likelihood and impact of severe space weather events on the resilience of nuclear power and safeguards monitoring.
严重空间天气事件对核电和保障监督的恢复力的可能性和影响。
- 批准号:
2908918 - 财政年份:2027
- 资助金额:
-- - 项目类别:
Studentship
Proton, alpha and gamma irradiation assisted stress corrosion cracking: understanding the fuel-stainless steel interface
质子、α 和 γ 辐照辅助应力腐蚀开裂:了解燃料-不锈钢界面
- 批准号:
2908693 - 财政年份:2027
- 资助金额:
-- - 项目类别:
Studentship
Field Assisted Sintering of Nuclear Fuel Simulants
核燃料模拟物的现场辅助烧结
- 批准号:
2908917 - 财政年份:2027
- 资助金额:
-- - 项目类别:
Studentship
Assessment of new fatigue capable titanium alloys for aerospace applications
评估用于航空航天应用的新型抗疲劳钛合金
- 批准号:
2879438 - 财政年份:2027
- 资助金额:
-- - 项目类别:
Studentship
Developing a 3D printed skin model using a Dextran - Collagen hydrogel to analyse the cellular and epigenetic effects of interleukin-17 inhibitors in
使用右旋糖酐-胶原蛋白水凝胶开发 3D 打印皮肤模型,以分析白细胞介素 17 抑制剂的细胞和表观遗传效应
- 批准号:
2890513 - 财政年份:2027
- 资助金额:
-- - 项目类别:
Studentship
Understanding the interplay between the gut microbiome, behavior and urbanisation in wild birds
了解野生鸟类肠道微生物组、行为和城市化之间的相互作用
- 批准号:
2876993 - 财政年份:2027
- 资助金额:
-- - 项目类别:
Studentship
相似国自然基金
“合金标准”下测量误差校正模型及其在体育运动数据中的应用
- 批准号:10801133
- 批准年份:2008
- 资助金额:17.0 万元
- 项目类别:青年科学基金项目
相似海外基金
Evaluating the Combined Effects of Stress and Exposure on the Deterioration Rate of Concrete
评估应力和暴露对混凝土劣化率的综合影响
- 批准号:
342535-2013 - 财政年份:2017
- 资助金额:
-- - 项目类别:
Discovery Grants Program - Individual
Evaluating the Combined Effects of Stress and Exposure on the Deterioration Rate of Concrete
评估应力和暴露对混凝土劣化率的综合影响
- 批准号:
342535-2013 - 财政年份:2016
- 资助金额:
-- - 项目类别:
Discovery Grants Program - Individual
Evaluating the Combined Effects of Stress and Exposure on the Deterioration Rate of Concrete
评估应力和暴露对混凝土劣化率的综合影响
- 批准号:
342535-2013 - 财政年份:2015
- 资助金额:
-- - 项目类别:
Discovery Grants Program - Individual
Evaluating the Combined Effects of Stress and Exposure on the Deterioration Rate of Concrete
评估应力和暴露对混凝土劣化率的综合影响
- 批准号:
342535-2013 - 财政年份:2014
- 资助金额:
-- - 项目类别:
Discovery Grants Program - Individual
Evaluating the Combined Effects of Stress and Exposure on the Deterioration Rate of Concrete
评估应力和暴露对混凝土劣化率的综合影响
- 批准号:
342535-2013 - 财政年份:2013
- 资助金额:
-- - 项目类别:
Discovery Grants Program - Individual
Evaluating the Combined Effects of Stress and Deterioration in Concrete Subjected to Deleterious Environments
评估有害环境下混凝土的应力和劣化的综合影响
- 批准号:
342535-2012 - 财政年份:2012
- 资助金额:
-- - 项目类别:
Discovery Grants Program - Individual
Rat Models of Alcohol Dependence for Evaluating Combined Medication Effects
用于评估综合药物效应的酒精依赖大鼠模型
- 批准号:
8101962 - 财政年份:2008
- 资助金额:
-- - 项目类别:
Rat Models of Alcohol Dependence for Evaluating Combined Medication Effects
用于评估综合药物效应的酒精依赖大鼠模型
- 批准号:
7527804 - 财政年份:2008
- 资助金额:
-- - 项目类别:
Rat Models of Alcohol Dependence for Evaluating Combined Medication Effects
用于评估综合药物效应的酒精依赖大鼠模型
- 批准号:
8302395 - 财政年份:2008
- 资助金额:
-- - 项目类别:
Rat Models of Alcohol Dependence for Evaluating Combined Medication Effects
用于评估综合药物效应的酒精依赖大鼠模型
- 批准号:
7655484 - 财政年份:2008
- 资助金额:
-- - 项目类别: