Evaluating the combined effects of environmental pollutants on the evolution of antimicrobial resistance

评估环境污染物对抗菌素耐药性演变的综合影响

• 批准号: 2859345
• 金额: --
• 依托单位: UNIVERSITY OF EXETER
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2859345
• 关键词: Evaluating; combined; effects; environmental; pollutants

Project BackgroundAntimicrobial resistance (AMR) is one of the greatest threats to modern society. The environment is increasingly recognised as playing an important role in the evolution, emergence, and dissemination of AMR. Antibiotics enter the environment from a variety of sources, where they reside at low concentrations that have been shown to select for AMR. However, most research to date has only studied effects of single antibiotics, despite the fact antibiotics in the environment are found in complex mixtures with other pollutants that could co-select for AMR. Project Aims and MethodsA growing body of research has demonstrated that the minimal selective concentrations of antibiotics can be very low, similar to concentrations of antibiotics measured in the environment. Antibiotic pollution may therefore select for antimicrobial resistance in the environment. However, many other environmental pollutants exhibit antimicrobial activity, and these may also generate a selective pressure that favours resistant bacteria. This project will explore the potential mixture effects of antibiotics and other pollutants on the evolution of antimicrobial resistance. We encourage applicants to be actively involved in the design and direction of the research.

项目背景抗微生物抵抗（AMR）是对现代社会的最大威胁之一。环境越来越被认为在AMR的进化，出现和传播中起着重要作用。抗生素从多种来源进入环境，它们以低浓度的居民为生，这些抗生素已被证明为AMR选择。然而，迄今为止，大多数研究仅研究了单抗生素的作用，尽管在环境中存在抗生素与其他可以共同选择AMR的抗生素的事实。项目的目标和方法不断增长的研究体验表明，最低的选择性抗生素浓度可能非常低，类似于环境中测得的抗生素浓度。因此，抗生素污染可以选择环境中的抗菌抗性。然而，许多其他环境污染物表现出抗菌活性，这些污染物也可能产生有利于抗性细菌的选择性压力。该项目将探讨抗生素和其他污染物对抗菌耐药性进化的潜在混合作用。我们鼓励申请人积极参与研究的设计和方向。