New Ruthenium Carbene Complexes for Olefin Metathesis

描述（由申请人提供）：本文所述的研究方案旨在制备具有新型配体的钌络合物以实现合成上有用的复分解反应。具体而言，努力将集中在稳定的亚甲基络合物的开发一个实用的乙烯醇分解反应，和设计的手性配体集，以完成对映选择性复分解反应。乙烯醇分解是一种交叉复分解反应，其中乙烯用作交叉伴侣，可用于有机合成以使烯烃脱同系物，并作为降解工具以确定天然产物的结构。通用对映选择性催化剂的开发将进一步扩大烯烃复分解反应在有机和高分子化学中的应用。为了实现这些目标，将探索新的卡宾配体结构。

DESCRIPTION (provided by applicant): The research proposal described herein is aimed at the preparation of ruthenium complexes with novel ligands to effect synethetically useful metathesis reactions. Specifically, efforts will be focused on the stabilization of a methylidene complex for the development of a practical ethenolysis reaction, and the design of a chiral ligand set in order to accomplish enantioselective metathesis reactions. Ethenolysis, the cross metathesis reaction where ethylene is used as the cross-partner, is useful in organic synthesis to dehomologate olefins, and as a degradation tool to determine the structure of natural products. The development of general enantioselective catalysts would further extend applicability of olefin metathesis in organic and polymer chemistries. New carbene ligand architectures will be explored in order to realize these goals.