Development of Catalysts for C=C and C-N Bond Forming Reactions

项目描述：本研究项目旨在开发高效形成碳-碳双键和碳-氮单键的新型催化剂。为指导K99阶段提出的研究将与Robert H.GRubbs教授一起进行一到两年的时间，并将涉及发现新的基于Ru的烯烃歧化催化剂。努力将重点放在空间要求很高的烯烃和其他底物的闭环和交叉歧化反应上，这些反应对其他商业可用的催化剂系统构成了挑战。独立棒阶段将专注于发现过渡金属络合物，这些络合物可以通过C-H活化过程促进碳-氮单键的形成。拟议目标的实现将使氮原子能够迅速进入原本不活跃的碳氢键。所建议的催化剂系统也很容易适应不对称工艺的发展。由于含氮产物的不对称合成在药物化学和药物化学中发挥着重要作用，这一贡献最终将有助于发现用于治疗人类疾病的化合物。项目相关性：由于合成化学家不断努力寻找新的和改进的构建分子的方法，可以用于治疗和预防人类疾病的分子的发现成为可能。改进这些生物相关分子的制备技术可以加快药物发现过程，最终有助于公众健康。

DESCRIPTION (provided by applicant): Project Description: This research program aims to develop new catalysts for the efficient formation of carbon-carbon double bonds and carbon-nitrogen single bonds. The research proposed for the Mentored K99 Phase will be carried out over one to two years with Professor Robert H. Grubbs and will involve the discovery of new ruthenium-based olefin metathesis catalysts. Efforts will focus on ring-closing and cross metathesis reactions of sterically demanding olefins, and other substrates that are challenging for other commercially available catalyst systems. The Independent ROD Phase will focus on the discovery of transition metal complexes that can promote the formation of carbon-nitrogen single bonds via C-H activation processes. Realization of the proposed goals will allow rapid introduction of nitrogen atoms at otherwise unreactive carbon-hydrogen bonds. The proposed catalyst systems are also readily adapted for the development of asymmetric processes. Since the asymmetric synthesis of nitrogen-containing products plays an important role in medicinal and pharmaceutical chemistry, this contribution will ultimately facilitate the discovery of compounds for the treatment of human illnesses. Project Relevance: The discovery of molecules that can be used for the treatment and prevention of human diseases is enabled by continued efforts of synthetic chemists to find new and improved ways of constructing molecules. Improving the technology by which these biologically relevant molecules can be prepared accelerates the drug discovery process, which ultimately aids the public health.