Development of Catalysts for C=C and C-N Bond Forming Reactions

项目描述：该研究项目旨在开发新型催化剂，用于有效形成碳-碳双键和碳-氮单键。K99指导阶段的研究将由Robert H.格拉布斯和将涉及新的铼基烯烃复分解催化剂的发现。努力将集中在空间要求高的烯烃的闭环和交叉复分解反应，以及对其他市售催化剂系统具有挑战性的其他底物。独立ROD阶段将专注于发现过渡金属络合物，这些络合物可以通过C-H活化过程促进碳-氮单键的形成。所提出的目标的实现将允许在否则不反应的碳-氢键处快速引入氮原子。所提出的催化剂体系也容易适用于不对称方法的开发。由于含氮产物的不对称合成在医学和药物化学中起着重要的作用，这一贡献将最终促进用于治疗人类疾病的化合物的发现。项目相关性：通过合成化学家不断努力寻找新的和改进的构建分子的方法，能够发现可用于治疗和预防人类疾病的分子。改进制备这些生物相关分子的技术可以加速药物发现过程，最终有助于公众健康。

DESCRIPTION (provided by applicant): Project Description: This research program aims to develop new catalysts for the efficient formation of carbon-carbon double bonds and carbon-nitrogen single bonds. The research proposed for the Mentored K99 Phase will be carried out over one to two years with Professor Robert H. Grubbs and will involve the discovery of new ruthenium-based olefin metathesis catalysts. Efforts will focus on ring-closing and cross metathesis reactions of sterically demanding olefins, and other substrates that are challenging for other commercially available catalyst systems. The Independent ROD Phase will focus on the discovery of transition metal complexes that can promote the formation of carbon-nitrogen single bonds via C-H activation processes. Realization of the proposed goals will allow rapid introduction of nitrogen atoms at otherwise unreactive carbon-hydrogen bonds. The proposed catalyst systems are also readily adapted for the development of asymmetric processes. Since the asymmetric synthesis of nitrogen-containing products plays an important role in medicinal and pharmaceutical chemistry, this contribution will ultimately facilitate the discovery of compounds for the treatment of human illnesses. Project Relevance: The discovery of molecules that can be used for the treatment and prevention of human diseases is enabled by continued efforts of synthetic chemists to find new and improved ways of constructing molecules. Improving the technology by which these biologically relevant molecules can be prepared accelerates the drug discovery process, which ultimately aids the public health.