Microfluidics to explore the uptake of nanoparticles by endothelial cells

微流体技术探索内皮细胞对纳米粒子的摄取

• 批准号: DP240101579
• 负责人: A/Prof Khashayar Khoshmanesh
• 金额: $ 34.02万
• 依托单位: RMIT University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP240101579
• 关键词: Microfluidics; explore; uptake; nanoparticles; endothelial

This project aims to develop microfluidic technologies for generating lipid nanoparticles with customised properties and investigating their delivery to endothelial cells under various flow dynamics. The project expects to advance our fundamental knowledge of biophysical and biological mechanisms underlying the uptake of lipid nanoparticles by endothelial cells. Expected outcomes of this project include enhanced delivery of nanoparticles to vessel walls. This should provide significant benefits, such as establishing a framework for designing future nano delivery systems, which would benefit Australian biotechnology industries.

该项目旨在开发微流体技术，用于生成具有定制特性的脂质纳米颗粒，并研究其在各种流动动力学下向内皮细胞的递送。该项目预计将推进我们对内皮细胞摄取脂质纳米颗粒的生物物理和生物机制的基础知识。该项目的预期成果包括增强纳米颗粒向血管壁的输送。这将带来重大的好处，例如为设计未来的纳米输送系统建立一个框架，这将有利于澳大利亚的生物技术产业。