Microfluidics to explore the uptake of nanoparticles by endothelial cells

微流体技术探索内皮细胞对纳米粒子的摄取

• 批准号: DP240101579
• 负责人: A/Prof Khashayar Khoshmanesh
• 金额: $ 34.02万
• 依托单位: RMIT University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP240101579
• 关键词: Microfluidics; explore; uptake; nanoparticles; endothelial

This project aims to develop microfluidic technologies for generating lipid nanoparticles with customised properties and investigating their delivery to endothelial cells under various flow dynamics. The project expects to advance our fundamental knowledge of biophysical and biological mechanisms underlying the uptake of lipid nanoparticles by endothelial cells. Expected outcomes of this project include enhanced delivery of nanoparticles to vessel walls. This should provide significant benefits, such as establishing a framework for designing future nano delivery systems, which would benefit Australian biotechnology industries.

该项目旨在开发微流控技术，以生成具有定制性质的脂质纳米颗粒，并研究其在不同流动动力学下向内皮细胞的输送。该项目希望促进我们对内皮细胞摄取脂质纳米粒的生物物理和生物学机制的基础知识。该项目的预期结果包括将纳米颗粒更好地输送到血管壁。这应该会带来显著的好处，例如为设计未来的纳米输送系统建立一个框架，这将使澳大利亚的生物技术产业受益。