Microfluidic platforms for studying foam cell formation in vessels

用于研究血管中泡沫细胞形成的微流体平台

• 批准号: LP190100728
• 负责人: A/Prof Khashayar Khoshmanesh
• 金额: $ 30.51万
• 依托单位: RMIT University
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-02-15 至 2024-02-14
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP190100728
• 关键词: Microfluidic; platforms; studying; foam; cell

This project aims to create technology platforms, utilising microfluidics and machine learning, to study the fundamental biological processes underlying the accumulation of immune cells underneath the vessel wall, which is known as foam cell formation. This project expects to deliver technologies, which facilitate mimicking and analysis of the complex dynamics of the human vessels in a more accurate, time- and cost-effective manner. The expected outcome will be cutting-edge tools and techniques to better understand the fundamental biological mechanisms driving foam cell formation. This should facilitate the development of future cardiovascular drug discovery technologies, which would benefit the biotechnology and pharmaceutical industries.

该项目旨在创建技术平台，利用微流体和机器学习，研究血管壁下免疫细胞积累的基本生物过程，即泡沫细胞形成。该项目希望提供技术，以更准确、更及时、更经济的方式模拟和分析人类血管的复杂动态。预期的结果将是尖端的工具和技术，以更好地理解驱动泡沫细胞形成的基本生物学机制。这将促进未来心血管药物发现技术的发展，这将有利于生物技术和制药工业。