Air Quality Improvements of The Animal Facility
动物设施的空气质量改善
基本信息
- 批准号:6907819
- 负责人:
- 金额:$ 63.46万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2005
- 资助国家:美国
- 起止时间:2005-07-01 至 2009-06-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
DESCRIPTION (provided by applicant): The Schepens Eye Research Institute is a major center for vision research affiliated with the Department of Ophthalmology at Harvard Medical School. The mission of The Schepens is to conduct research that will lead to understanding the mechanisms of diseases that cause visual dysfunction and blindness. In order to achieve this goal, the faculty uses and creates a variety of laboratory animal models that are essential for studying the pathogenesis and treatment pf a diverse group of ocular diseases. Maintaining these laboratory animals is vital to the success of this research. For this reason, our animal facility must conform to the highest standards and provide a first-rate program for: housing, caging, maintaining the animal environment, and providing veterinary medical care. This application supports renovations to the Animal Facility that improve: (i) the heating, ventilation, and air conditioning (HVAC) system, and (ii) provide special caging for rodents that will compliment the barrier/containment housing. There are 2 specific aims. Aim 1 will install new ductwork and louvers for the newly installed HVAC 25,000 cfm rooftop unit. This duct system will provide: (i) better air control and distribution within the facility, (ii) improved ventilation patterns in animal rooms, and (iii) better control of temperature and humidity in individual animal rooms. The combined HVAC and duct system will provide routine maintenance of positive and negative pressure within animal rooms and zones within the facility. The Animal Facility's existing Siemens Environmental Monitoring System will be adapted to the new air distribution system. Aim 2 will provide 12 new Micro-ventilated mouse cage racks that will maximize the use of animal housing space, and improve air quality within cages and surrounding rooms. As a result of these improvements, the animal care and use program at The Schepens will operate in a manner that exceeds many provisions of the Guide for the Care and Use of Laboratory Animals. This will significantly improve the quality of vision research conducted by the Faculty at the Schepens.
描述(申请人提供):谢彭斯眼科研究所是一个主要的视觉研究中心,附属于哈佛医学院眼科。Schepens的任务是进行研究,以了解导致视觉功能障碍和失明的疾病的机制。为了实现这一目标,教员们使用并创建了各种实验动物模型,这些模型对于研究各种眼部疾病的发病机制和治疗至关重要。维护这些实验动物对这项研究的成功至关重要。出于这个原因,我们的动物设施必须符合最高标准,并在以下方面提供一流的项目:住房、笼子、维护动物环境和提供兽医护理。该应用程序支持对动物设施的翻新,以改善:(I)供暖、通风和空调(HVAC)系统,以及(Ii)为啮齿动物提供特殊的笼子,以补充屏障/安全壳。有两个具体目标。AIM 1将为新安装的暖通空调25,000 CFM屋顶机组安装新的管网和百叶窗。这个管道系统将提供:(I)更好的空气控制和设施内的分布;(Ii)改善动物房间的通风模式;以及(Iii)更好地控制个别动物房间的温度和湿度。综合的暖通空调和风管系统将在设施内的动物房间和区域内提供正负压力的日常维护。动物设施现有的西门子环境监测系统将适应新的空气分配系统。Aim 2将提供12个新的微通风老鼠笼架,最大限度地利用动物住房空间,并改善笼子和周围房间的空气质量。作为这些改进的结果,谢彭斯的动物护理和使用计划的运作方式将超过《实验动物护理和使用指南》的许多规定。这将显著提高谢彭斯学院进行的视觉研究的质量。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Michael S Gilmore其他文献
Michael S Gilmore的其他文献
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{{ truncateString('Michael S Gilmore', 18)}}的其他基金
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10569041 - 财政年份:2022
- 资助金额:
$ 63.46万 - 项目类别:
The Role of Enterococcus Unique Hypothetical EF1909 in Intrinsic β-lactam Resistance
肠球菌独特的假设 EF1909 在内在 β-内酰胺耐药性中的作用
- 批准号:
10464409 - 财政年份:2022
- 资助金额:
$ 63.46万 - 项目类别:
New understanding of LTA as a determinant of daptomycin susceptibility in VRE E. faecium
对 LTA 作为 VRE 屎肠球菌达托霉素敏感性决定因素的新认识
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9926227 - 财政年份:2019
- 资助金额:
$ 63.46万 - 项目类别:
New understanding of LTA as a determinant of daptomycin susceptibility in VRE E. faecium
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9810471 - 财政年份:2019
- 资助金额:
$ 63.46万 - 项目类别:
Subproject 3 New Approaches to Treatment and Prevention of Antibiotic Resistant Infection
子项目3 治疗和预防抗生素耐药感染的新方法
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9151288 - 财政年份:2016
- 资助金额:
$ 63.46万 - 项目类别:
Molecular Basis for Ocular Surface Tropism in Conjunctivitis
结膜炎眼表向性的分子基础
- 批准号:
9264533 - 财政年份:2014
- 资助金额:
$ 63.46万 - 项目类别:
Molecular Basis for Ocular Surface Tropism in Conjunctivitis
结膜炎眼表向性的分子基础
- 批准号:
8670576 - 财政年份:2014
- 资助金额:
$ 63.46万 - 项目类别:
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