Biosafety for Dogs and Cats in Models of Human Diseases

人类疾病模型中狗和猫的生物安全

• 批准号: 6902981
• 负责人: JOHN H WOLFE
• 金额: $ 63.9万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-06-20 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6902981
• 关键词: animal care; animal colony; biohazard control; building /facility design /renovation; cats; disease /disorder model; dogs; epizootiology; veterinary medicine

DESCRIPTION (provided by applicant): The overall goal of this submission is to improve disease prevention and improve barrier housing in the large animal vivarium in the Ryan Veterinary Hospital of the University of Pennsylvania (VHUP) of the School of Veterinary Medicine (SVM). Funding is requested to replace the old, frequently inoperable, and inadequately sanitizing cage washer for the dog and cat colonies; to isolate the experimental surgery suite from nosocomial infections and control exposure to BSL-2 agents; and to correct deficiencies in the housing spaces for immunologically deficient animals and other models. This renovation will directly benefit at least 15 investigators with more than $5 million in annual direct support to conduct biomedical research on cat and dog disease models. The major research user group is the cross-departmental, inter-disciplinary Center for Comparative Medical Genetics (CCMG). The CCMG investigators maintain more than 25 independent breeding colonies of dog and cat models of human genetic diseases. This is the largest collection of such models in the world, and many of these valuable mutations do not exist anywhere else. The types of inherited diseases include cardiac abnormalities, inborn errors of metabolism, immune deficiencies, skin disorders, retinal degeneration diseases, and hematologic disorders. Studies utilizing these animals include mode of inheritance, mutation analysis, mechanisms of pathogenesis, gene therapy, stem cell transplantation, and other basic and translational research areas. The vivarium is also used by other investigators in the SVM who have NIH-funded research for dogs and cats in parasitology, pain, sepsis, cancer, and other disorders. The vivarium urgently needs upgrading to insure that these rare and fragile disease breeding colonies are protected from animal diseases and that modern A-BSL-2 experiments can be conducted with protection for both the animals and the scientific and vivarium staff.

描述（由申请人提供）： 这项提交的总体目的是改善预防疾病，改善宾夕法尼亚大学瑞安兽医医院（VHUP）兽医学院（SVM）的大型动物体内住房。要求资金代替旧的，经常无法使用的旧且不足的笼子洗衣机，用于狗和猫殖民地；从医院感染中分离实验手术套件并控制暴露于BSL-2药物；并纠正用于免疫学性动物和其他模型的住房空间中的缺陷。这种翻新将直接受益于至少15名年度直接支持，以进行猫和狗病模型的生物医学研究。主要的研究用户组是跨部门，跨学科医学遗传学中心（CCMG）。 CCMG研究人员维持了25个以上的狗的独立育种菌落和人类遗传疾病的猫模型。这是世界上最大的此类模型的集合，其中许多有价值的突变都不存在。遗传性疾病的类型包括心脏异常，新陈代谢的天生错误，免疫缺陷，皮肤疾病，视网膜变性疾病和血液学疾病。利用这些动物的研究包括遗传模式，突变分析，发病机理的机制，基因治疗，干细胞移植以及其他基本和转化研究领域。 SVM的其他研究人员还使用了NIH资助的狗和猫研究研究中的其他研究人员，从而在寄生虫，疼痛，败血症，癌症和其他疾病中使用了Vivarium。迫切需要升级的幼虫以确保保护这些罕见和脆弱的疾病繁殖菌落免受动物疾病的侵害，并且可以为动物以及科学和维瓦里姆的工作人员保护现代A-BSL-2实验。