EFFECTS OF ENVIRONMENTAL TOXICANTS ON HEALTH

环境有毒物质对健康的影响

• 批准号: 7170667
• 负责人: GREG MAYER
• 金额: $ 12.2万
• 依托单位: MOUNT DESERT ISLAND BIOLOGICAL LAB
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2006-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7170667
• 关键词: educational resource design /development; functional /structural genomics; health science research support; postgraduate education; training

DESCRIPTION (provided by applicant): This proposal seeks continued support for Maine's Biomedical Research Infrastructure Network (BRIN) through an IdeA Network of Biomedical Research Excellence (INBRE) among seven Maine institutions, with the Mount Desert Island Biological Laboratory (MDIBL) serving as lead institution. The overall goal of this INBRE is to augment and strengthen Maine's biomedical research capacity by further developing our collaborative network composed of two premier research institutions (MDIBL, The Jackson Laboratory), two undergraduate and graduate degree granting institutions (The University of Maine, College of the Atlantic), and three undergraduate degree granting institutions (Bates College, Bowdoin College, Colby College) INBRE will build on the successful foundation established by BRIN by further strengthening biomedical research infrastructure through a multidisciplinary research network with a thematic scientific focus in comparative functional genomics and with expanded opportunities for developing the biomedical research competitiveness of Maine scientists. The common hypothesis within the research network is that conservation of primary structure across orthologous genomic regions of vertebrate models, including elasmobranch, teleost, avian and mammalian species predicts the location of functional domains in proteins of interest, and also identifies potential novel regulatory sequences that can be tested in functional assays using these comparative models Maine's INBRE will a) provide research support and core facilities to junior faculty, postdoctoral fellows and graduate students at participating institutions, b) create year-round and seasonal research and training opportunities for undergraduate students at participating institutions, c) provide outreach activities to students and faculty at all undergraduate institutions and community colleges in Maine, and through the above, d) serve as a pipeline for undergraduate students to pursue health research careers and enhance the scientific and technical knowledge of Maine's work force.

描述（由申请人提供）：本提案旨在通过七个缅因州机构之间的生物医学研究卓越（INBRE）的IdeA网络，继续支持缅因州的生物医学研究基础设施网络（BRIN），其中芒特沙漠岛生物实验室（MDIBL）作为牵头机构。该INBRE的总体目标是通过进一步发展我们由两个主要研究机构组成的合作网络，增强和加强缅因州的生物医学研究能力（MDIBL，杰克逊实验室），两个本科和研究生学位授予机构（缅因州大学、大西洋学院），以及三所本科学位授予机构（贝茨学院，鲍登学院，科尔比学院）INBRE将在BRIN建立的成功基础上，通过多学科研究网络进一步加强生物医学研究基础设施，该研究网络的科学专题重点是比较功能基因组学，并扩大发展生物医学研究的机会。缅因州科学家的研究竞争力。研究网络中的共同假设是，脊椎动物模型（包括板鳃类、硬骨鱼、鸟类和哺乳动物物种）的直链基因组区域的一级结构保守性预测了感兴趣蛋白质中功能结构域的位置，并且还鉴定了潜在的新型调节序列，所述调节序列可以使用这些比较模型在功能测定中进行测试。缅因州的INBRE将a）为参与院校的初级教员、博士后研究员和研究生提供研究支持和核心设施，B）为参与院校的本科生创造全年和季节性的研究和培训机会，c）为缅因州所有本科院校和社区学院的学生和教师提供外展活动，并通过上述活动，d）作为本科生追求健康研究事业和提高缅因州的劳动力的科学和技术知识的管道。