Creating Cytochrome Wires for Sustainable Biotechnology

为可持续生物技术创建细胞色素线

• 批准号: 2869036
• 金额: --
• 依托单位: University of East Anglia
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2869036
• 关键词: Creating; Cytochrome; Wires; Sustainable; Biotechnology

Proteins containing chains of close-packed heme cofactors are a fascinating class of biomolecular nanowire. Produced by bacteria these cytochrome proteins have evolved to conduct electrons over distances ranging from nanometres to tens of microns. Their properties underpin the production of green electricity by microbial fuel cells and offer exciting prospects for renewable components in emerging electronic technologies. Inspired by these opportunities, this project will work at the interface of biological and physical sciences to enhance the properties of cytochrome wires by equipping them with non-canonical amino acids.The project builds on our expertise studying the structure and function of cytochrome biowires from Shewanella oneidensis and will make extensive use of genetic-code expansion for the incorporation of non-canonical amino acids.

蛋白质含有紧密堆积的血红素辅因子链，是一类迷人的生物分子纳米线。这些细胞色素蛋白由细菌产生，已经进化到可以在从纳米到几十微米的距离内传导电子。它们的特性支持微生物燃料电池生产绿色电力，并为新兴电子技术中的可再生组件提供了令人兴奋的前景。受这些机会的启发，该项目将在生物科学和物理科学的界面上工作，通过为细胞色素线配备非规范氨基酸来增强其性能。该项目建立在我们研究希瓦氏菌细胞色素生物线结构和功能的专业知识基础上，并将广泛使用遗传密码扩展来整合非规范氨基酸。