UPGRADE OF VARIABLE FREQUENCY PULSED EPR FACILITY
变频脉冲 EPR 设施升级
基本信息
- 批准号:6877479
- 负责人:
- 金额:$ 20.45万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2005
- 资助国家:美国
- 起止时间:2005-03-01 至 2007-02-28
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
DESCRIPTION (provided by applicant):
This proposal requests funding to substantially upgrade the variable frequency pulsed EPR Facility in the Department of Chemistry at the University of Arizona by acquiring a high field (1.99 Tesla) magnet system, including power supply, liquid helium cryostat with accessories and temperature controller, and a timing/ data acquistion module. Presently, a single 1.4 Tesla magnet system that is an integral part of the Bruker ESP300E X-band CW EPR spectrometer must also serve the requirements for the three unique broadband-pulsed EPR spectrometers that operate over the 2-8, 8-18 and 26-40 GHz ranges. This arrangement greatly limits the research output of the EPR Facility because only one type of EPR experiment can be running at any one time. In addition, the frequent changing among the spectrometers for the single available magnet system usurps valuable instrument time that could be used for productive research. Moreover, the 1.4 Tesla field of the existing magnet is too low to enable EPR signals with g < 2.0 to be studied by high resolution pulsed EPR techniques near 40 GHz. This high frequency range is essential for pulsed EPR studies of several of the biomolecules of the investigators of this proposal, including investigation of 14N, 15N interactions in heme proteins and Rieske proteins and 17-O in molybdenum enzymes, all of which have g-values spread below g=2. The requested 1.99 Tesla magnet system with power supply, liquid helium cryostat with accessories and temperature controller, and a timing/data acquisition module, will handle the ever increasing demands for experiments on metallobiomolecules using the existing 8-18 and 26-40 GHz pulsed broadband EPR spectrometers as well as provide increased access of users to the CW X-band and pulsed S/C band (2-8 GHz) spectrometers.
描述(由申请人提供):
项目成果
期刊论文数量(9)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Sirtuin inhibitor sirtinol is an intracellular iron chelator.
Sirtuin抑制剂Sirtinol是一种细胞内铁螯合剂。
- DOI:10.1039/c5cc00829h
- 发表时间:2015-03-25
- 期刊:
- 影响因子:0
- 作者:Gautam R;Akam EA;Astashkin AV;Loughrey JJ;Tomat E
- 通讯作者:Tomat E
Prodigiosin analogue designed for metal coordination: stable zinc and copper pyrrolyldipyrrins.
- DOI:10.1021/ic5008439
- 发表时间:2014-07-21
- 期刊:
- 影响因子:4.6
- 作者:Chang, Tsuhen M.;Sinharay, Sanhita;Astashkin, Andrei V.;Tomat, Elisa
- 通讯作者:Tomat, Elisa
Intracellular reduction/activation of a disulfide switch in thiosemicarbazone iron chelators.
- DOI:10.1039/c4mt00153b
- 发表时间:2014-10
- 期刊:
- 影响因子:0
- 作者:Akam EA;Chang TM;Astashkin AV;Tomat E
- 通讯作者:Tomat E
Optimization of pulsed DEER measurements for Gd-based labels: choice of operational frequencies, pulse durations and positions, and temperature.
- DOI:10.1007/s00723-012-0434-6
- 发表时间:2013-06
- 期刊:
- 影响因子:1
- 作者:Raitsimring, A.;Astashkin, A. V.;Enemark, J. H.;Kaminker, I.;Goldfarb, D.;Walter, E. D.;Song, Y.;Meade, T. J.
- 通讯作者:Meade, T. J.
Pulsed dipolar spectroscopy distance measurements in biomacromolecules labeled with Gd(III) markers.
- DOI:10.1016/j.jmr.2011.02.010
- 发表时间:2011-05
- 期刊:
- 影响因子:0
- 作者:Song Y;Meade TJ;Astashkin AV;Klein EL;Enemark JH;Raitsimring A
- 通讯作者:Raitsimring A
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JOHN H ENEMARK的其他文献
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{{ truncateString('JOHN H ENEMARK', 18)}}的其他基金
UPGRADE OF VARIABLE FREQUENCY PULSED EPR FACILITY: BIOCHEMISTRY
变频脉冲 EPR 设施升级:生物化学
- 批准号:
7166412 - 财政年份:2005
- 资助金额:
$ 20.45万 - 项目类别:
XRAY ROTATION CAMERA STUDIES OF SULFITE OXIDASE
亚硫酸氧化酶的 X 射线旋转摄像机研究
- 批准号:
6586604 - 财政年份:2002
- 资助金额:
$ 20.45万 - 项目类别:
XRAY ROTATION CAMERA STUDIES OF SULFITE OXIDASE
亚硫酸氧化酶的 X 射线旋转摄像机研究
- 批准号:
6658571 - 财政年份:2002
- 资助金额:
$ 20.45万 - 项目类别:
XRAY ROTATION CAMERA STUDIES OF SULFITE OXIDASE
亚硫酸氧化酶的 X 射线旋转摄像机研究
- 批准号:
6437522 - 财政年份:2001
- 资助金额:
$ 20.45万 - 项目类别:
XRAY ROTATION CAMERA STUDIES OF SULFITE OXIDASE
亚硫酸氧化酶的 X 射线旋转摄像机研究
- 批准号:
6119426 - 财政年份:1999
- 资助金额:
$ 20.45万 - 项目类别:
XRAY ROTATION CAMERA STUDIES OF SULFITE OXIDASE
亚硫酸氧化酶的 X 射线旋转摄像机研究
- 批准号:
6250766 - 财政年份:1997
- 资助金额:
$ 20.45万 - 项目类别:
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