Identifying patient invariant parameters for diagnosis using terahertz sensing

使用太赫兹传感识别患者不变参数进行诊断

• 批准号: 2869381
• 金额: --
• 依托单位: University of Warwick
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2869381
• 关键词: Identifying; patient; invariant; parameters; diagnosis

Terahertz (1012 Hz, THz) pulsed imaging is a new technique with high resolution and has only emerged recently as a potential new clinical tool for medical imaging. It is a totally non-destructive and non-ionising imaging modality as the average power of the pulse for producing the radiation is as small as 100 nW. The radiation produced is focused onto the sample of interest and then detected coherently. A point measurement is analogous to an ultrasound A-scan. Reflections off different layers are used to determine the structure at various depths. THz light is very sensitive to hydrogen bonds. By Fourier transforming the time-domain data, useful spectroscopic information can also be revealed. Potential applications range from security imaging to medical diagnosis, but the analysis and instrumentation needs to be tailored for each application investigated. THz light can be generated and detected using photoconductive antennas. The useable frequency range of a THz system depends on the photoconductive devices as well as other factors such as optical alignment.We have developed a handheld THz probe that has been used in the first clinical trials of their kind at the University hospital in Coventry. The aim of this project is to take and analyse patient and volunteer data a view to developing classification algorithms for skin conditions. For example, it may be possible to use THz imaging to detect early stages of skin cancer, or the lateral extent of tumours that are beneath the skin's surface, and not yet visible. This project will give the student experience in Optics, coding, signal processing and machine learning.

太赫兹（1012 Hz，THz）脉冲成像是一种高分辨率的新技术，最近才出现作为一个潜在的新的临床医学成像工具。这是一种完全无损和非电离的成像模式，因为用于产生辐射的脉冲的平均功率小至100 nW。所产生的辐射被聚焦到感兴趣的样品上，然后被相干地检测。点测量类似于超声A扫描。不同层的反射被用来确定不同深度的结构。太赫兹光对氢键非常敏感。通过对时域数据进行傅立叶变换，还可以揭示有用的光谱信息。潜在的应用范围从安全成像到医疗诊断，但分析和仪器需要针对所研究的每个应用进行定制。太赫兹光可以使用光导天线产生和检测。THz系统的可用频率范围取决于光电导器件以及其他因素，如光学对准。我们已经开发了一种手持式THz探头，该探头已在考文垂大学医院的第一次临床试验中使用。该项目的目的是收集和分析患者和志愿者的数据，以开发皮肤状况的分类算法。例如，有可能使用太赫兹成像来检测皮肤癌的早期阶段，或者皮肤表面下尚未可见的肿瘤的横向范围。该项目将为学生提供光学，编码，信号处理和机器学习方面的经验。