权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Function and regulation of mucosal associated invariant T cells in the lung

肺粘膜相关不变T细胞的功能和调节

基本信息

批准号：
10646480
负责人：
Qi yang
金额：
$ 55.66万
依托单位：
RUTGERS BIOMEDICAL AND HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-11-24 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10646480
关键词：
1 year old 7 year old Adoptive Transfer Adult Allergens Alternaria Anabolism Anti-Inflammatory Agents Asthma Biology Biopsy Biopsy Specimen Brain Death Bronchi CD4 Positive T Lymphocytes Cell Count Cells Child Data Development Engineered Probiotics Escherichia coli Exhibits Frequencies Genes House Dust Mite Allergens Human Immune Impairment Individual Inflammatory Inflammatory Response Lung Lung diseases Lymphoid Cell Mediating Metabolic Molecular Mucous Membrane Mus Organ Donor Pathogenicity Pathway interactions Probiotics Production Proliferating Property Public Health Publishing Regulation Repression Riboflavin Risk Role Sampling Sputum Structure of parenchyma of lung T-Lymphocyte Testing Therapeutic Work airway hyperresponsiveness airway immune response airway inflammation allergic airway inflammation asthmatic patient cellular engineering combat insight microbial mouse model novel novel strategies peripheral blood respiratory examination response single-cell RNA sequencing

项目摘要

Project Summary/Abstract Asthma remains a serious public health threat with unmet therapeutic needs. The development of successful therapies relies a more in-depth understanding of the immune subsets and pathways involved. MAIT cells are innate-like T cells that recognize microbial riboflavin metabolites presented by MR1 and can function through both TCR dependent and independent pathways. Interestingly, previous studies indicated an inverse association between MAIT cells and human asthma. The precise role of MAIT cells in asthma development and exacerbation, however, remains unknown. Our recently published work and additionally preliminary data indicate a striking anti-inflammatory role for MAIT cells in allergic airway inflammation. We hypothesize that a deficiency of MAIT cells in asthma patients contributes to exacerbated airway inflammatory responses to allergens, and that increasing MAIT cell numbers may help alleviate allergen-induced airway inflammation and hyperresponsiveness. Using fresh lung samples from deceased organ donors, we will examine the abundance and molecular properties of lung-resident MAIT cells in severe asthma patients and control individuals without lung diseases. We will use MAIT cell deficient mice and adoptive transfer strategies to interrogate the specific roles of MAIT cells in allergic airway inflammation. Finally, we will test whether boosting the number of MAIT cells by an engineered probiotic strain can help alleviate ongoing airway inflammation induced by common allergens.

项目总结/文摘