Investigating lipid metabolism and its impact on our immune system

研究脂质代谢及其对免疫系统的影响

• 批准号: 2869548
• 金额: --
• 依托单位: University of East Anglia
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2869548
• 关键词: Investigating; lipid; metabolism; its; impact

During homeostasis the systemic immune response relies on the expansion and differentiation of blood stem cells. In response to infection, these stem cells promote the rapid immune response by generating innate and adaptive immune cells that are recruited into the liver and the intestine to support the response to infection. During infection the blood stem cells require energy to proliferate and differentiate into immune cells, however were this energy comes from is not fully understood. To gain a better understanding of the mechanisms regulating the energy requierment for blood production during infectoin will enable us to propose strategies to preserve and improve the systemic immune function and to overall maintain whole-body health. Therefore, the aim of this project is to define the mechanisms underpinning metabolic reqyuirement of haematopoiesis during infection. Specifically, we will determine the role of various lipid metabolites and regulators in these processes.

在稳态期间，全身免疫应答依赖于造血干细胞的扩增和分化。在对感染的反应中，这些干细胞通过产生先天性和适应性免疫细胞来促进快速免疫反应，这些免疫细胞被招募到肝脏和肠道中以支持对感染的反应。在感染过程中，造血干细胞需要能量来增殖和分化成免疫细胞，然而这种能量来自哪里并不完全清楚。为了更好地了解在感染期间调节血液产生的能量需求的机制，将使我们能够提出保护和改善全身免疫功能以及整体维持全身健康的策略。因此，本项目的目的是确定感染期间造血代谢需求的机制。具体来说，我们将确定各种脂质代谢产物和调节剂在这些过程中的作用。