Tackling the fatty liver by targeting the gut

通过针对肠道来解决脂肪肝

• 批准号: 2869577
• 金额: --
• 依托单位: University of East Anglia
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2869577
• 关键词: Tackling; fatty; liver; targeting; gut

Obesity has epidemic proportions in the UK as more than 60% of adults are overweighted and 33% have fatty liver. Poor dietary habits (western diets) are the may contributors to liver steatosis but also have broader effects, including profound changes in the gut microbiome composition and impaired barrier function associated with increased permeability of the intestine.The aim of this project is to improve our understanding of the mechanisms mediating the development of a fatty liver and the subsequent inflammation. This will enable the proposal of potential targets to preserve gut-liver health and prevent disease progression associated to poor dietary habits, which will be investigated in this project.

在英国，肥胖是一种流行病，超过60%的成年人超重，33%的人患有脂肪肝。不良的饮食习惯（西方饮食）是肝脏脂肪变性的可能原因，但也有更广泛的影响，包括肠道微生物组成的深刻变化和与肠道通透性增加相关的屏障功能受损。该项目的目的是提高我们对脂肪肝的发展和随后的炎症的机制的理解。这将有助于提出潜在目标，以保持肠道-肝脏健康并预防与不良饮食习惯相关的疾病进展，这将在本项目中进行调查。