The unique and complementary functions of PCSK7 and PCSK9 in cardiometabolic health and disease
The unique and complementary functions of PCSK7 and PCSK9 in cardiometabolic health and disease
批准号:
488392
负责人:
Seidah Nabil G
金额:
$89.17万
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2023
资助国家:
加拿大
项目状态:
未结题
起止时间:
2023-09-01 至 2028-09-01
中文摘要
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英文摘要
We discovered a mammalian family of 9 enzymes (PCSK1-PCSK9), of which PCSK7 and PCSK9 are unique for their key roles in the regulation of cholesterol & lipid metabolism, with strong translational potential in cardiovascular diseases, inflammatory, vascula
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CRC Tier 1
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批准号:364795
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项目类别:
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资助金额:$101.99万
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财政年份:2016
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负责人:Seidah Nabil G
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依托单位:
The proprotein convertases and their partners in health and disease
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批准号:332925
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项目类别:Operating Grants
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资助金额:$274.02万
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财政年份:2015
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负责人:Seidah Nabil G
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依托单位:
The sex/tissue-specific regulation of the LDLR in absence of PCSK9 activity and its clinical relevance
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批准号:339847
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项目类别:Operating Grants
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资助金额:$10.93万
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财政年份:2015
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负责人:Seidah Nabil G
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依托单位:
How does substrate cleavage by the proprotein convertases impact on physiology and pathology?
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批准号:265386
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项目类别:Operating Grants
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资助金额:$7.29万
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财政年份:2012
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负责人:Seidah Nabil G
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依托单位:
Validation of PCSK9 single domain antibodies in cholesterol regulation in humanized mice
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批准号:268513
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项目类别:Operating Grants
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资助金额:$13.56万
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财政年份:2012
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负责人:Seidah Nabil G
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依托单位:
PCSK9 and Cardiovascular Disease
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批准号:229041
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项目类别:Operating Grants
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资助金额:$0.73万
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财政年份:2011
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负责人:Seidah Nabil G
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依托单位:
CANADA RESEARCH CHAIRHOLDER / TITULAIRE DE CHAIRE DE RECHERCHE DU CANADA
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批准号:204273
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项目类别:
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资助金额:$101.99万
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财政年份:2009
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负责人:Seidah Nabil G
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依托单位:
PCSK9: Functions and mechanisms of action in liver and adipocytes
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批准号:188345
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项目类别:Operating Grants
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资助金额:$57.98万
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财政年份:2009
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负责人:Seidah Nabil G
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依托单位:
The roles of PCSK9 and SKI-1 in Hepatitis C infection
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批准号:171106
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项目类别:Operating Grants
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资助金额:$58.52万
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财政年份:2008
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负责人:Seidah Nabil G
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依托单位:
海外基金