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The unique and complementary functions of PCSK7 and PCSK9 in cardiometabolic health and disease

The unique and complementary functions of PCSK7 and PCSK9 in cardiometabolic health and disease
PCSK7 和 PCSK9 在心脏代谢健康和疾病中的独特和互补功能
批准号:
488392
负责人:
Seidah Nabil G
金额:
$89.17万
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2023
资助国家:
加拿大
项目状态:
未结题
起止时间:
2023-09-01 至 2028-09-01

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中文摘要
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英文摘要
We discovered a mammalian family of 9 enzymes (PCSK1-PCSK9), of which PCSK7 and PCSK9 are unique for their key roles in the regulation of cholesterol & lipid metabolism, with strong translational potential in cardiovascular diseases, inflammatory, vascula
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CRC Tier 1
  • 批准号:
    364795
  • 项目类别:
  • 资助金额:
    $101.99万
  • 财政年份:
    2016
  • 负责人:
    Seidah Nabil G
  • 依托单位:
The proprotein convertases and their partners in health and disease
The sex/tissue-specific regulation of the LDLR in absence of PCSK9 activity and its clinical relevance
How does substrate cleavage by the proprotein convertases impact on physiology and pathology?
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