COBRE: U NEL: ADMIN: NEBRASKA REDOX BIOLOGY CENTER

COBRE：U NEL：管理员：内布拉斯加州氧化还原生物中心

• 批准号: 7171057
• 负责人: RUMA V BANERJEE
• 金额: $ 44.16万
• 依托单位: UNIVERSITY OF NEBRASKA LINCOLN
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7171057
• 关键词: cooperative study; health science research support; interdisciplinary collaboration; oxidation reduction reaction

DESCRIPTION (provided by applicant): This IDeA proposal presents a detailed plan to create a rnultidisciplinary Center for Biomedical Research Excellence (COBRE) in Nebraska for Redox Biology. The Center will link scientists at the two leading research-active institutions in the state - the UN-Lincoln and the UNMC - in a collaborative pursuit to unravel fundamental problems in redox biology that impact the pathogenesis of a number of diseases including some cancers, arthritis and cardiovascular diseases and the progression of natural phenomena such as aging. The objectives of the proposed Center are (i) to enhance biomedical research capacity in the state by creating an infrastructure that will strategically link strong research programs in redox biology at the two institutions and (ii) to mentor a cadre of junior faculty to independent funding success at NIH. These objectives will be met by providing a rich and rigorous mentoring environment for junior investigators, by bolstering core facilities, by fostering collaborations among scientists at both institutions and by recruiting five additional faculty members with research interests in the area of redox biology to ensure the critical mass of scientists necessary to sustain a nationally visible and internationally recognized Center. A key design feature for the organization of the Center is the mentoring of each of the five developing faculty members by an established investigator with similar research interests and a successful track record of funding at NIH. As these project leaders transition to funding independence, their projects will be replaced by ones led by the newly recruited faculty members. A Director with the vision, scientific expertise and administrative experience necessary to provide effective leadership will be primarily responsible for steering the Center. She will be counseled by members of the Mentoring Council, comprising five established scientists at the Nebraska institutions, and guided by an External Advisory Council (EAC) comprising eight outstanding scientists, five of whom are members of the National Academy of Sciences, and all of whom have agreed to serve in this capacity. The synergistic environment resulting from the creation of the Center will enrich the culture of research in the state, will enliven its community of biomedical scientists and will elevate the quality and offerings of key core facilities.

描述（由申请人提供）：本IDEA提案提出了在内布拉斯加州为氧化还原生物学创建多学科生物医学研究卓越中心（COBRE）的详细计划。该中心将把该州两个领先的研究活跃机构的科学家联系起来-联合国林肯大学和联合国海洋管理委员会-共同致力于解决氧化还原生物学中的基本问题，这些问题影响了一些疾病的发病机制，包括一些癌症，关节炎和心血管疾病以及自然现象的进展，如衰老。拟议中心的目标是：（一）通过创建一个基础设施，将战略性地将两个机构的氧化还原生物学强有力的研究项目联系起来，以提高该州的生物医学研究能力;（二）指导一批初级教师在NIH获得独立资助。 这些目标将通过为初级研究人员提供丰富而严格的指导环境来实现，通过加强核心设施，通过促进两个机构的科学家之间的合作，并通过招聘另外五名在氧化还原生物学领域具有研究兴趣的教师，以确保维持一个全国可见和国际公认的中心所需的科学家的临界质量。该中心组织的一个关键设计特点是由一位具有类似研究兴趣和在NIH成功获得资助的调查员指导五名发展中的教员。随着这些项目负责人过渡到资金独立，他们的项目将被新招聘的教师领导的项目所取代。一名具备有效领导所需的远见、科学专门知识和行政经验的主任将主要负责指导中心的工作。她将由指导理事会成员提供咨询，该理事会由内布拉斯加州各机构的五位知名科学家组成，并由外部咨询理事会（EAC）提供指导，该理事会由八位杰出科学家组成，其中五位是国家科学院的成员，所有这些人都同意以这种身份服务。 该中心的创建所产生的协同环境将丰富该州的研究文化，将活跃其生物医学科学家社区，并将提高关键核心设施的质量和产品。