ANTICANCER MECHANISMS OF LYCOPENE ACTION

描述(由申请者提供)：北达科他州INBRE的目标是通过为该州内的研究型大学、学士学位机构和部落学院提供服务来建设生物医学研究能力。其具体目标是：1)在六个以本科为主的机构(PUI)启动具有竞争力的、可持续的研究计划；2)增加PUI中选择接受生物医学高级培训的学生的数量；3)增加部落学院的学生进入理科学士学位课程的人数；4)加强该州获得支持生物医学研究的计算和电子资源的机会；以及5)加强研究型大学现有的蛋白质组学和生物学核心设施，使其成为可持续和有效的科学网络培训和服务中心。该计划的核心是PUIS的发展研究方案，围绕“健康与环境”这一主题而建立。这一广泛的主题细分为三个子主题：1)农药和非哺乳动物生物标记物；2)营养、生长和发育；以及3)遗传因素。来自北达科他州大学和北达科他州州立大学的资深生物医学科学家将指导九名个人调查人员，他们位于六个普伊斯。蛋白质组学和生物核心设施 研究型大学将为PUI学生和调查人员提供专业服务和培训。生物信息学核心将提供计算设施和工作，以增加全州范围内获得生物医学研究电子资源的机会。招收学生将主要通过他们参与INBRE调查人员在本国校园的研究项目来进行。科学网络还将为来自邻近部落大学的学生提供研究机会。推广核心计划旨在增强部落学院加强其科学入门课程的能力，从而提高部落大学生过渡到四年制科学方案的准备水平。

DESCRIPTION (provided by applicant): The goal of North Dakota INBRE is to build biomedical research capacity by serving research universities, baccalaureate institutions, and tribal colleges within the state. The specific aims are to: 1) initiate competitive, sustainable research programs at six predominantly undergraduate institutions (PUIs); 2) increase the number of students from PUIs who choose to pursue advanced training in the biomedical sciences; 3) increase the number of students from tribal colleges who matriculate into baccalaureate degree programs in the sciences; 4) enhance the state's access to computational and electronic resources supporting biomedical research; and 5) enhance existing proteomics and biology core facilities at the research universities to make them sustainable and effective training and service centers for the scientific network. The centerpiece of this plan is the development research programs at PUIs, built around the thematic focus of "Health and the Environment". This broad theme is subdivided into three sub-themes: 1) pesticides and non-mammalian biomarkers; 2) nutrition, growth and development; and 3) genetic factors. Nine individual investigators, located at six PUIs, will be mentored by established biomedical scientists from the University of North Dakota and North Dakota State University. Proteomics and biology core facilities at the research universities will provide specialized services and training for PUI students and investigators. A bioinformatics core will provide computational facilities and work to increase state-wide access to electronic resources for biomedical research. Recruitment of students will be primarily through their involvement in the research projects of INBRE investigators on their home campuses. The scientific network will also offer research opportunities to students from neighboring tribal colleges. An Outreach Core is designed to empower tribal colleges to strengthen their introductory science curricula so as to increase the level of preparation of tribal college students for transitioning to four-year science programs.