ANTICANCER MECHANISMS OF LYCOPENE ACTION

描述（由申请人提供）：北达科他州INBRE的目标是通过为研究型大学、学士学位机构和州内的部落学院提供服务，建立生物医学研究能力。具体目标是：1)在六所主要的本科院校（PUIs）发起有竞争力的、可持续的研究项目；2)增加选择攻读生物医学科学高级培训的PUIs学生人数；3)增加部落学院学生进入理科学士学位课程的人数；4)加强国家对支持生物医学研究的计算和电子资源的获取；5)加强研究型大学现有的蛋白质组学和生物学核心设施，使其成为科学网络可持续和有效的培训和服务中心。该计划的核心是各大学围绕“健康与环境”这一主题开展的发展研究方案。这个广泛的主题被细分为三个子主题：1)农药和非哺乳动物生物标志物；2)营养、生长发育；3)遗传因素。9名个人调查人员将在北达科他州立大学和北达科他州立大学的知名生物医学科学家的指导下，在6个研究单位工作。蛋白质组学和生物学核心设施在

DESCRIPTION (provided by applicant): The goal of North Dakota INBRE is to build biomedical research capacity by serving research universities, baccalaureate institutions, and tribal colleges within the state. The specific aims are to: 1) initiate competitive, sustainable research programs at six predominantly undergraduate institutions (PUIs); 2) increase the number of students from PUIs who choose to pursue advanced training in the biomedical sciences; 3) increase the number of students from tribal colleges who matriculate into baccalaureate degree programs in the sciences; 4) enhance the state's access to computational and electronic resources supporting biomedical research; and 5) enhance existing proteomics and biology core facilities at the research universities to make them sustainable and effective training and service centers for the scientific network. The centerpiece of this plan is the development research programs at PUIs, built around the thematic focus of "Health and the Environment". This broad theme is subdivided into three sub-themes: 1) pesticides and non-mammalian biomarkers; 2) nutrition, growth and development; and 3) genetic factors. Nine individual investigators, located at six PUIs, will be mentored by established biomedical scientists from the University of North Dakota and North Dakota State University. Proteomics and biology core facilities at the research universities will provide specialized services and training for PUI students and investigators. A bioinformatics core will provide computational facilities and work to increase state-wide access to electronic resources for biomedical research. Recruitment of students will be primarily through their involvement in the research projects of INBRE investigators on their home campuses. The scientific network will also offer research opportunities to students from neighboring tribal colleges. An Outreach Core is designed to empower tribal colleges to strengthen their introductory science curricula so as to increase the level of preparation of tribal college students for transitioning to four-year science programs.