COBRE: UND: MASS SPECTROMETRY CORE FACILITY

描述(由申请人提供)：这项建议是在北达科他州大学建立一个神经退行性疾病病理生理学的生物医学研究卓越中心(COBRE)。该中心的总体目标是描述导致神经元变性的细胞机制。拟议的中心将由五个项目组成，涉及6名初级教职员工，每个项目都检查神经退化过程的一个独特方面。这五个项目，连同拟议的核心设施、教师招聘和行政核心，将极大地帮助我们实现我们的长期目标：发展一个高度互动和协作的研究小组，专注于了解神经变性的病因，并开发预防或阻止神经病理的治疗方法。这次会议的具体目标是：1.为科布雷项目主任制定成功的独立研究项目，使他们能够获得校外R01研究补助金。2.)通过发展支持所有研究人员的核心设施，加强北达科他大学医学院和健康科学学院的研究基础设施。3.)通过招聘一名资深神经学家和四名初级教员到联合国发展和医疗服务中心，扩大神经科学领域的生物医学教员研究，他们的研究主题是我们的科布雷。这些新招聘的教员将在联合国儿童基金会建立一大批研究人员，他们的研究专长领域是免费赠送的神经科学领域。4.)在北达科他州大学建立一个国家和国际公认的神经科学研究卓越中心。Cobre SPECIAL AIMS的成功完成将在联合国儿童基金会建立起神经科学研究卓越中心的声誉，吸引对神经科学研究感兴趣的教职员工、博士后研究员和研究生。我们的中心将在获得培训资助、计划项目资助和中心资助方面具有很强的竞争力，这将使神经科学研究卓越中心在科布尔奖之外继续下去。

DESCRIPTION (provided by applicant): This proposal is to establish a Center of Biomedical Research Excellence (COBRE) on the Pathophysiology of neurodegenerative diseases at the University of North Dakota. The overall objective of this Center is to characterize the cellular mechanisms that contribute to neuronal degeneration. The proposed Center will consist of five projects involving 6 junior faculty members, each of which examines a unique aspect of the neurodegenerative process. These five projects, together with the proposed core facilities, faculty recruitments and administrative core will greatly assist us in meeting our long term goal: To develop a highly interactive and collaborative research group focused on understanding the etiology of neurodegeneration and developing therapeutic approaches to prevent or halt neuropathology. The Specific Aims of this COBRE are: 1.) To develop successful independent research projects for the COBRE project directors that will enable them to obtain extramural R01 research grants. 2.) To enhance research infrastructure at the University of North Dakota School of Medicine & Health Sciences (UNDSMHS) through the development of core facilities to support all investigators. 3.) To expand biomedical faculty research in the area of neuroscience through the recruitment of an established senior level neuroscientist and four junior faculty members to UNDSMHS whose research is in the theme of our COBRE. These new faculty recruits will establish a critical mass of researchers at UNDSMHS whose areas of research expertise are in complimentary areas of neuroscience. 4.) To establish a nationally and internationally recognized Center of Neuroscience Research Excellence at the University of North Dakota. The successful completion of COBRE Specific Aims will establish a reputation at UNDSMHS as a Center of Neuroscience Research Excellence that will attract faculty, postdoctoral fellows, and graduate students interested in neuroscience research. Our Center will then be highly competitive for obtaining training grants, program project grants and center grants that will allow for the continuation of the Center of Neuroscience Research Excellence beyond the COBRE award.