Gene - environment interactions as predictors of clinical outcome in At Risk Mental State

这笔赠款旨在确定与精神分裂症的发展、严重程度和结局有关的相互作用的遗传、临床和环境决定因素。实验和风险评估生物信息学研究将促进将其转化为临床实践。这将使(I)确定可改变的生物和认知机制，以及(Ii)建立可用于早期预测向精神障碍过渡和监测结果的工具。这项研究将确定将精神分裂症的遗传易感性转化为显性疾病的因素。压力、物质使用和其他环境特征的关键风险因素将作为对有早期症状的年轻人的随机临床试验的一部分进行研究，这些年轻人有精神分裂症的直接风险。这项研究是一个更大的国际研究计划的一部分，该计划致力于阐明精神分裂症的易感性是如何发展以及如何最终预防的。

The grant aims to identify the interactive genetic, clinical and environmental determinants involved in the development, severity and outcome of schizophrenia. Translation to clinical practice will be facilitated by experimental and risk assessment bioinformatics research. This will enable the (i) identification of modifiable biological and cognitive mechanisms and (ii) construction of tools which can be used for the early prediction of transition to psychotic disorder and outcome monitoring. This study will identify the factors that translate genetic vulnerability to schizophrenia into overt illness. The key risk factors of stress and substance use and other environmental features will be studied as part of randomised clinical trials in young people with early symptoms who are at immediate risk of schizophrenia. This study forms part of a much larger international program of research focusing on clarifying how the vulnerability to schizophrenia develops and how it can ultimately be prevented