Gene - environment interactions as predictors of clinical outcome in At Risk Mental State

基因-环境相互作用作为高危精神状态临床结果的预测因素

• 批准号: nhmrc : 567215
• 负责人: Prof Patrick Mcgorry
• 金额: $ 68.92万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Strategic Awards
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/gene-environment-interactions-mental-state/83190
• 关键词: Gene; environment; interactions; predictors; clinical

The grant aims to identify the interactive genetic, clinical and environmental determinants involved in the development, severity and outcome of schizophrenia. Translation to clinical practice will be facilitated by experimental and risk assessment bioinformatics research. This will enable the (i) identification of modifiable biological and cognitive mechanisms and (ii) construction of tools which can be used for the early prediction of transition to psychotic disorder and outcome monitoring. This study will identify the factors that translate genetic vulnerability to schizophrenia into overt illness. The key risk factors of stress and substance use and other environmental features will be studied as part of randomised clinical trials in young people with early symptoms who are at immediate risk of schizophrenia. This study forms part of a much larger international program of research focusing on clarifying how the vulnerability to schizophrenia develops and how it can ultimately be prevented

该补助金旨在确定参与精神分裂症的发展，严重程度和结果的相互作用的遗传，临床和环境决定因素。实验和风险评估生物信息学研究将促进临床实践的转化。这将使（i）识别可改变的生物和认知机制和（ii）构建可用于早期预测向精神病性障碍转变和结果监测的工具。这项研究将确定将精神分裂症的遗传易感性转化为显性疾病的因素。压力和物质使用以及其他环境特征的关键风险因素将作为随机临床试验的一部分进行研究，这些试验针对有早期症状的年轻人，他们有患精神分裂症的直接风险。这项研究是一个更大的国际研究项目的一部分，该项目的重点是澄清精神分裂症的脆弱性是如何发展的，以及如何最终预防精神分裂症。