Gene-Environment Interplay and Alcohol Use among Racially-Ethnically Diverse Youth: A Developmentally and Culturally Informed Approach

种族-民族多元化青年中的基因-环境相互作用和酒精使用：一种发展和文化知情的方法

• 批准号: 10779197
• 负责人: Jinni Su
• 金额: $ 33.33万
• 依托单位: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-18 至 2028-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10779197
• 关键词: 10 year old; Acceleration; Adolescence; Adolescent; Adult; African American; Age; Alcohol abuse; Alcohol consumption; Alcohols; American; Behavior; Behavioral Genetics; Black race; Brain; Buffers; Cause of Death; Child; Child Health; Child Rearing; Childhood; Complex; Data; Development; Disease; Environment; Environmental Risk Factor; Equation; Etiology; European; European ancestry; Genes; Genetic; Genetic Risk; Health Disparities Research; Hispanic; Human; Impulsivity; Individual; Intervention; Latinx; Link; Mediating; Mission; Modeling; Outcome; Pathway interactions; Polygenic Traits; Population; Population Heterogeneity; Prevention; Prevention program; Process; Public Health; Research; Risk; Risk Factors; Role; Sampling; Science; Sex Differences; Shapes; Stressful Event; Survival Analysis; Symptoms; Temperament; Testing; Twin Multiple Birth; United States; United States National Institutes of Health; Youth; alcohol risk; alcohol use disorder; alcohol use initiation; cognitive development; contextual factors; cultural values; deter alcohol use; early alcohol use; ethnic diversity; ethnic minority population; gene environment interaction; genome-wide; genomic data; health disparity; high risk; insight; intervention program; peer; perceived discrimination; person centered; phenotypic data; prospective; protective factors; racial discrimination; racial diversity; racial minority population; societal costs; substance use; trait; underage drinking

PROJECT SUMMARY/ABSTRACT Alcohol is the most widely used substance and the third-leading preventable cause of death in the United States. Initiation of alcohol use typically occurs in adolescence, and early onset alcohol use (< age 15) has been associated with prolonged negative outcomes such as increased risk for AUD. The development of alcohol use and AUD is influenced by genetic and environmental factors, and the complex interactions among them (i.e., gene-environment interaction or GE). Yet, the majority of genetic and GE research has been 1) conducted with populations of European ancestry, and 2) focused on alcohol outcomes among individuals who have already initiated alcohol use or developed AUD. Thus, there is limited understanding of GE processes in racially-ethnically diverse populations, and how genetic risk manifests earlier in development in order to inform early prevention and intervention efforts. Furthermore, despite culture being an important context that shapes human behavior, cultural risk and protective factors have been largely overlooked in GE research. We seek to advance the understanding of etiology of alcohol use and AUD among racially-ethnically diverse populations by taking a developmentally and culturally informed approach to study GE processes. This project draws data from the ongoing Adolescent Brain and Cognitive Development (ABCD) Study, which includes rich genomic and phenotypic data from a longitudinal sample (N = 11,875; 52.1% White, 15.0% Black, and 20.3% Hispanic/Latinx) of racially-ethnically diverse children from late childhood (9-10 years old) through adolescence. The project examines three research aims. First, we will characterize polygenic influences on adolescent alcohol use among racially-ethnically diverse youth. Using a genome-wide polygenic score (PRS) approach, we will examine the effects of multiple adult and child-based PRS for alcohol and related traits (e.g., externalizing, internalizing symptoms) on timing of progression through the stages (e.g., experimentation, initiation, regular use, and problematic use), and trajectories of alcohol use from late childhood to adolescence. Second, we will examine the role of multiple childhood precursors (i.e., impulsivity, externalizing, and internalizing symptoms) in mediating polygenic influences on alcohol use. Finally, we will investigate the role of cultural-contextual risk and protective factors (i.e., parenting, peer deviance, stressful life events, racial discrimination experiences, familism cultural value) in moderating genetic influences on childhood precursors and adolescent alcohol use. We will explore how the associations of genetic, cultural-contextual factors, childhood precursors, and alcohol use change from late childhood to adolescence by examining age and developmental differences, and exploring differences by sex and pubertal status. Findings will advance alcohol and health disparities sciences by elucidating developmental and environmental mechanisms linking genetic risk to alcohol use among racially-ethnically diverse adolescents, providing critical insights for alcohol use prevention and intervention programs, including who is most at risk, what to target, and when to intervene.

项目总结/摘要 酒精是美国使用最广泛的物质，也是第三大可预防的死亡原因。 States.开始饮酒通常发生在青春期，早发性饮酒（<15岁） 与长期的负面结果相关，如AUD风险增加。的发展 酒精使用和AUD受遗传和环境因素的影响， 它们（即，基因-环境相互作用（Gene-environment interaction，G？然而，大多数遗传学和基因工程研究都是1） 与欧洲血统的人群进行，2）专注于酒精的结果， 已经开始饮酒或出现AUD。因此，人们对G/E过程的了解有限， 种族-民族多样化的人群，以及遗传风险如何在发育早期表现出来， 早期预防和干预措施。此外，尽管文化是一个重要的背景， 人类行为，文化风险和保护因素在很大程度上被忽略了在G-E研究。我们寻求 促进对不同种族人群中酒精使用和AUD病因学的理解 通过采取发展和文化知情的方法来研究GEE过程。本项目绘制数据 正在进行的青少年大脑和认知发展（ABCD）研究，其中包括丰富的基因组 纵向样本的表型数据（N = 11，875; 52.1%白色、15.0%黑色和20.3% 西班牙裔/拉丁裔）的不同种族的儿童从童年后期（9-10岁）到 青春期该项目审查了三个研究目标。首先，我们将描述多基因影响， 不同种族的青少年饮酒情况。使用全基因组多基因评分（PRS） 方法，我们将研究多种成人和儿童为基础的PRS对酒精和相关性状的影响（例如， 外化，内化症状）对各阶段进展的时间（例如，实验， 开始，经常使用和有问题的使用），以及从童年后期到青春期的酒精使用轨迹。 第二，我们将研究多种童年前体的作用（即，冲动，外化， 内化症状）在调节多基因对酒精使用的影响。最后，我们将研究 文化背景风险和保护因素（即，父母教养，同伴偏差，压力生活事件，种族 歧视的经验，家庭主义的文化价值）在调节遗传对儿童期前体的影响 和青少年酗酒的问题我们将探讨遗传，文化背景因素， 儿童期前兆和酒精使用的变化，从童年后期到青春期，通过检查年龄和 发育差异，并探索性别和青春期状态的差异。研究结果将推动酒精 通过阐明将遗传和健康差异联系在一起的发展和环境机制， 不同种族青少年饮酒的风险，为饮酒提供重要见解 预防和干预计划，包括谁是最危险的，什么目标，以及何时干预。