KY COBRE: TALIN-1 METASTISIS SUPPRESSOR IN LUNG CANCER

KY COBRE：TALIN-1 肺癌转移抑制剂

• 批准号: 7171383
• 负责人: Richard O. McCann
• 金额: $ 25.98万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-01 至 2006-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7171383
• 关键词: disease /disorder; health science research; molecular biology; molecular pathology; structural biology

DESCRIPTION (provided by applicant): The objective of the Center of Biomedical Research Excellence in the Molecular Basis of Human Disease (COBREMBHD) is to enhance the success of promising junior investigators at the University of Kentucky for competing for NIH grant support through the development of a research center focusing on understanding human disease at the molecular level. We will achieve this objective by: (1) assembling a group of established extramurally funded scientists who will serve as mentors for junior faculty serving as principal investigators on research projects. (2) providing these junior faculty with state-of-the-art training in concepts and techniques relevant to studying human disease with an emphasis on the application of structural biology to these projects, (3) establishing mentoring plans including milestones as the basis of the development program, (4) developing and supporting shared core facilities, (5) providing pilot grants for projects that will complement those of the junior faculty, (6) providing a seminar program stressing the latest advances in studying human diseases at the molecular level and techniques of structural biology and their application to biomedical research, (6) holding an annual retreat to evaluate and critique the progress of the junior faculty and (7) hiring promising new faculty to develop a critical mass of productive investigators in studying molecular aspects of human disease. Five tenure track Assistant Professors will serve as PIs on research projects that overlap in concepts and methodology. The junior investigators participating in the COBRE came from excellent postdoctoral experiences and are likely to benefit from the training program. Their projects apply one or more of the techniques of structural biology to studies related to human disease and have a high likelihood of developing into successful RO1 type research grants.

描述（由申请人提供）： 人类疾病分子基础卓越生物医学研究中心（COBREMBHD）的目标是通过发展一个专注于在分子水平上了解人类疾病的研究中心，提高肯塔基州大学有前途的初级研究人员竞争NIH资助的成功率。我们将通过以下方式实现这一目标： (1)召集一组由校外资助的科学家，他们将担任初级教师的导师，担任研究项目的主要调查员。(2)为这些初级教师提供与研究人类疾病相关的概念和技术方面的最先进的培训，重点是将结构生物学应用于这些项目，（3）建立指导计划，包括作为发展计划基础的里程碑，（4）开发和支持共享核心设施，（5）为补充初级教师的项目提供试点赠款，（6）提供一个研讨会计划，强调在分子水平上研究人类疾病的最新进展和结构生物学技术及其在生物医学研究中的应用，（6）举行年度务虚会，评估和批评初级教师的进展，（7）聘请有前途的新教师，以培养一批研究人类疾病分子方面的生产力调查人员。 五个终身职位的助理教授将担任研究项目的PI，在概念和方法上重叠。参加COBRE的初级研究人员来自优秀的博士后经验，并可能从培训计划中受益。他们的项目将一种或多种结构生物学技术应用于与人类疾病相关的研究，并且很有可能发展成为成功的RO 1类型研究赠款。