STRUCTURE AND NUCLEOLAR FUNCTION OF SARS N PROTEIN

SARS N蛋白的结构和核仁功能

• 批准号: 7171180
• 负责人: RAYMOND ROWLAND
• 金额: $ 6.7万
• 依托单位: UNIVERSITY OF KANSAS LAWRENCE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7171180
• 关键词: clinical research; health science research potential; protein structure function; structural biology

DESCRIPTION (provided by applicant): Five years of support are requested to establish a program for development of junior faculty with research interests in Protein Structure and Function, with the goal of enabling them to become fully competitive for NIH grant support. Four Ph.D.-granting institutions in Kansas are participating, including KU-Lawrence, K-State University, KU-School of Medicine, and Wichita State University. The Principal Investigator, co-investigator, and a strong group of established, NIH-funded faculty, along with outstanding scientists on an External Advisory Committee (EAC), will provide mentoring and assistance to new faculty, not only in establishing highly competitive research programs in the study of protein structure and function but in their overall development as academic scientists. Individual mentoring plans with specific milestones form the basis for the development program. This will be supplemented with a seminar series by prominent scientists alternating with research presentations by COBRE investigators and workshops dealing with technical aspects of protein analysis, publishing, grant writing, and lab management. One administrative and two scientific Cores will be established to administer the program and provide high caliber technical expertise and instrumentation. Protein Structure and Function was selected as a theme because (1) detailed understanding of proteins is the next great challenge in overcoming diseases, (2) a strong cadre of senior faculty in Kansas are working in this area, and (3) current and future hiring plans for new faculty throughout the State of Kansas emphasize studies in protein structure and function. This focus on multi-disciplinary research on proteins enables us to capitalize on recent University investments in research infrastructure, and to obtain substantial institutional support for the proposed program in the form of FTEs, new research instrumentation, and space. Six faculty have been selected for 2-3 years of support, based on scientific merit, relevance for the COBRE theme, potential to benefit from the mentoring program and the Core labs, and likelihood of developing their project to compete successfully for NIH grants in the future. Progress toward the goals of the Program will be monitored by self-study and by Internal and External Advisory Committees; the latter will also review proposals and applications from new junior faculty for COBRE support.

描述（由申请人提供）：要求五年的支持，以建立一个对蛋白质结构和功能研究感兴趣的初级教师发展计划，目标是使他们能够充分竞争NIH的资助支持。堪萨斯州有四所授予博士学位的机构参与其中，包括堪萨斯大学劳伦斯分校、堪萨斯州立大学、堪萨斯大学医学院和威奇托州立大学。首席研究员、联合研究员和一群由美国国立卫生研究院资助的教师，以及外部咨询委员会（EAC）的杰出科学家，将为新教师提供指导和帮助，不仅在蛋白质结构和功能研究方面建立具有高度竞争力的研究项目，而且在他们作为学术科学家的整体发展方面。具有特定里程碑的个人指导计划构成了开发计划的基础。此外，还将举办一系列由著名科学家主持的研讨会，其间穿插COBRE研究人员的研究报告，以及涉及蛋白质分析、出版、拨款写作和实验室管理等技术方面的讲习班。将建立一个行政中心和两个科学中心来管理该项目，并提供高水平的技术专长和仪器。选择蛋白质结构和功能作为主题是因为(1)对蛋白质的详细了解是克服疾病的下一个重大挑战，(2)堪萨斯州有强大的高级教师骨干在这一领域工作，(3)堪萨斯州目前和未来招聘新教师的计划强调蛋白质结构和功能的研究。这种对蛋白质的多学科研究的关注使我们能够利用大学最近在研究基础设施方面的投资，并以fte、新的研究仪器和空间的形式为拟议的项目获得大量的机构支持。根据科学价值，与COBRE主题的相关性，从指导计划和核心实验室中受益的潜力，以及发展他们的项目以在未来成功竞争NIH拨款的可能性，选择了6名教师进行2-3年的支持。将通过自学以及内部和外部咨询委员会监测实现方案目标的进展情况；后者还将审查新青年教师的建议和申请，以获得COBRE的支持。