COBRE: WI HOSP OF RI: P57KIP2 IN VENTRICULAR CARDIOMYOCYTE DIFFERENTIATION

COBRE：RI 的 WI HOSP：心室心肌细胞分化中的 P57KIP2

• 批准号: 7171211
• 负责人: Lazaros K. Kochilas
• 金额: $ 20.6万
• 依托单位: WOMEN AND INFANTS HOSPITAL-RHODE ISLAND
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7171211
• 关键词: histogenesis; vertebrate embryology

DESCRIPTION (provided by applicant): The scientific aims of this COBRE Program are to increase our understanding of cardiopulmonary development and help to develop strategies for new therapeutic interventions by defining how several of these events impact fetal and newborn development. We will examine: 1) The regulation of the cell cycle control protein p57Kip2 and its role in myocardial growth and differentiation; 2) The expression of the beta-1 adrenergic receptor (beta1AR) and its role in cardiac growth during the transition from the proliferative, embryonic period to postnatal life; 3) The signal transduction pathways mediating the effects of mechanical stretch on late embryonic/fetal lung development; 4) The spatio-temporal regulation of Fas/FasL in the respiratory epithelium and role in lung development and lung remodeling; 5) The role of the protooncogene c-myc in the regulation of the beta1AR gene expression; 5) the pathophysiological effects of disruption of the IL-10 gene and the STAT 6 signaling pathway on reproduction. The programmatic aims of this COBRE are to provide scientific and career mentorship to Junior Faculty in an interdisciplinary environment that fosters creativity and transdisciplinary collaboration in scientific approaches. We have recently completed construction of a new, state-of-the-art research facility. It houses successful, senior investigators as well as this group of young scientists, all of whom have demonstrated excellent potential for independent careers. This award will allow us to couple this new facility with the extramural support needed to allow these investigators to collaborate with leading scientists in their fields and to utilize contemporary appraches in cell and molecular biology to address important issues in the development of the mid-late gestation fetus. The combination of a supportive environment within a robust setting of inquiry and exploration will allow us to enhance/ensure their career trajectories as independent investigators. The clinical relevance of these areas is borne out by their high likelihood to identify important mechanisms for the regulation of fetal growth and the growth and differentiation of major organ systems. These areas are reflected in the special research expertise of the investigators participating in this Center Of Biological Research Excellence (COBRE) for Perinatal Biology. This project will be based at the Women and Infants' Hospital of Rhode Island. It will provide support for four full projects and 2 pilot projects of Junior Faculty who will me mentored by established investigators. An outstanding group of investigators from other centers will provide support and collaboration as the External Scientific Advisory Committee.

描述（由申请人提供）： COBRE计划的科学目标是增加我们对心肺发育的理解，并通过定义这些事件如何影响胎儿和新生儿发育来帮助制定新的治疗干预策略。我们将研究：1）细胞周期调控蛋白p57 Kip 2的调控及其在心肌生长和分化中的作用; 2）β 1肾上腺素能受体（β 1 AR）的表达及其在从增殖期、胚胎期到出生后的心脏生长中的作用; 3）介导机械牵张对晚期胚胎/胎儿肺发育影响的信号转导途径; 4）呼吸道上皮Fas/FasL的时空调控及其在肺发育和肺重塑中的作用; 5）原癌基因c-myc在β 1 AR基因表达调控中的作用; 5）IL-10基因和STAT 6信号通路的破坏对生殖的病理生理影响。 该COBRE的计划目标是在跨学科环境中为初级教师提供科学和职业指导，以促进科学方法的创造力和跨学科合作。我们最近完成了一个新的、最先进的研究设施的建设。它拥有成功的高级研究人员以及这群年轻的科学家，他们都表现出了独立职业的出色潜力。该奖项将使我们能够将这一新设施与所需的校外支持结合起来，使这些研究人员能够与各自领域的领先科学家合作，并利用细胞和分子生物学的当代方法来解决妊娠中晚期胎儿发育中的重要问题。在强大的调查和探索环境中的支持性环境的结合将使我们能够加强/确保他们作为独立调查员的职业轨迹。这些区域的临床相关性是由它们很可能确定调节胎儿生长和主要器官系统的生长和分化的重要机制所证实的。这些领域反映在参与围产期生物学卓越生物研究中心（COBRE）的研究人员的特殊研究专业知识中。该项目将设在罗得岛妇女和婴儿医院。它将为四个完整的项目和两个初级学院的试点项目提供支持，这些项目将由既定的研究人员指导。来自其他中心的优秀研究人员将作为外部科学咨询委员会提供支持和合作。