OK COBRE: GENETIC ASSOCIATION IN PEDIATRIC SLE PATIENTS

OK COBRE：儿童系统性红斑狼疮患者的遗传关联

• 批准号: 7171329
• 负责人: ANDREA L SESTAK
• 金额: $ 29.55万
• 依托单位: OKLAHOMA MEDICAL RESEARCH FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7171329
• 关键词: autoimmunity; clinical research; disease /disorder etiology; genetic susceptibility; human subject; immunogenetics; patient oriented research; systemic lupus erythematosus

DESCRIPTION (provided by applicant):The Oklahoma Medical Research Foundation (OMRF) herein proposes a site for a Center for Biomedical Research Excellence (COBRE) on "Molecular Mechanisms and Genetics of Autoimmunity." Research programs in immunology and rheumatic diseases were initiated over 20 years ago at the OMRF and have been steadily growing since. The faculty is responsible for a number of seminal discoveries and has made this an area of research excellence at the OMRF upon which to build this COBRE. We propose four Junior Investigators who have promising futures for biomedical research productivity in the genetics and molecular mechanisms of autoimmunity. Indeed, their projects should have an important impact upon our understanding of important autoimmune disease problems. These Junior Investigators are supported by eight exceptional Mentors, who will provide the guidance and advocacy so important for launching the successful careers of independent scientists. The projects proposed by the Junior Investigators will also be facilitated by a Nucleic Acid Analysis Core and a Data Analysis Core, both of which are directed by very experienced and knowledgeable staff scientists. Indeed, these cores will help efficiently and economically apply the most sophisticated technologies and methods to the problems being addressed in the projects performed by the Junior Investigators. Additional COBRE Junior Investigators will be recruited to this center making this a transitional mechanism for the development of many independent investigators, thereby sustaining the level of excellence now achieved in research into autoimmunity in Oklahoma. The synergies, collaborations, and directed effort of the COBRE will provide a much deeper level of understanding to human autoimmune diseases and will foster the independent career development of a strong group of Junior Investigators.

描述（由申请人提供）：俄克拉荷马州医学研究基金会（OMRF）在此提议建立一个生物医学研究卓越中心（COBRE），研究“自身免疫的分子机制和遗传学”。“免疫学和风湿性疾病的研究项目是20多年前在OMRF启动的，此后一直在稳步增长。该学院负责许多开创性的发现，并使其成为OMRF的一个卓越研究领域，并在此基础上建立COBRE。我们提出了四个初级研究员谁有前途的生物医学研究生产力的遗传学和自身免疫的分子机制。事实上，他们的项目应该对我们理解重要的自身免疫性疾病问题产生重要影响。这些初级研究员由八位杰出的导师支持，他们将为独立科学家的成功职业生涯提供重要的指导和宣传。初级研究员提出的项目还将得到核酸分析核心和数据分析核心的促进，这两个核心都由经验丰富、知识渊博的科学家指导。事实上，这些核心将有助于有效和经济地将最先进的技术和方法应用于初级调查员执行的项目中所解决的问题。该中心将招募更多的COBRE初级研究者，使其成为许多独立研究者发展的过渡机制，从而维持俄克拉荷马州自身免疫研究目前达到的卓越水平。COBRE的协同作用，合作和定向努力将为人类自身免疫性疾病提供更深层次的理解，并将促进一组强大的初级研究者的独立职业发展。