COBRE: U KS: P3: PROTEIN-PROTEIN INTERACTIONS TRANSCRIPTION ACTIVATN BY RHAR

COBRE：UK KS：P3：RHAR 的蛋白质-蛋白质相互作用转录激活

• 批准号: 7171175
• 负责人: SUSAN M EGAN
• 金额: $ 6.61万
• 依托单位: UNIVERSITY OF KANSAS LAWRENCE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7171175
• 关键词: clinical research; health science research potential; protein structure function; structural biology

DESCRIPTION (provided by applicant): Five years of support are requested to establish a program for development of junior faculty with research interests in Protein Structure and Function, with the goal of enabling them to become fully competitive for NIH grant support. Four Ph.D.-granting institutions in Kansas are participating, including KU-Lawrence, K-State University, KU-School of Medicine, and Wichita State University. The Principal Investigator, co-investigator, and a strong group of established, NIH-funded faculty, along with outstanding scientists on an External Advisory Committee (EAC), will provide mentoring and assistance to new faculty, not only in establishing highly competitive research programs in the study of protein structure and function but in their overall development as academic scientists. Individual mentoring plans with specific milestones form the basis for the development program. This will be supplemented with a seminar series by prominent scientists alternating with research presentations by COBRE investigators and workshops dealing with technical aspects of protein analysis, publishing, grant writing, and lab management. One administrative and two scientific Cores will be established to administer the program and provide high caliber technical expertise and instrumentation. Protein Structure and Function was selected as a theme because (1) detailed understanding of proteins is the next great challenge in overcoming diseases, (2) a strong cadre of senior faculty in Kansas are working in this area, and (3) current and future hiring plans for new faculty throughout the State of Kansas emphasize studies in protein structure and function. This focus on multi-disciplinary research on proteins enables us to capitalize on recent University investments in research infrastructure, and to obtain substantial institutional support for the proposed program in the form of FTEs, new research instrumentation, and space. Six faculty have been selected for 2-3 years of support, based on scientific merit, relevance for the COBRE theme, potential to benefit from the mentoring program and the Core labs, and likelihood of developing their project to compete successfully for NIH grants in the future. Progress toward the goals of the Program will be monitored by self-study and by Internal and External Advisory Committees; the latter will also review proposals and applications from new junior faculty for COBRE support.

描述(由申请者提供)：要求提供五年的支持，以建立一个在蛋白质结构和功能方面有研究兴趣的初级教员发展计划，目标是使他们能够充分竞争NIH的拨款支持。堪萨斯州的四所授予博士学位的机构将参与其中，包括KU-Lawrence、K-State University、KU-School of Medicine和Wichita State University。首席研究员、联合研究员和一批由NIH资助的资深教员，以及外部咨询委员会(EAC)中的杰出科学家，将为新教员提供指导和帮助，不仅在蛋白质结构和功能研究方面建立具有高度竞争力的研究项目，而且在他们作为学术科学家的全面发展方面也是如此。具有特定里程碑的个人指导计划构成了发展计划的基础。此外，著名科学家还将举办一系列研讨会，与科布雷研究人员的研究报告和研讨会交替进行，这些研讨会涉及蛋白质分析、出版、拨款申请和实验室管理的技术方面。将建立一个行政核心和两个科学核心来管理该方案，并提供高素质的技术专长和仪器。之所以选择蛋白质结构和功能作为主题，是因为(1)对蛋白质的详细了解是战胜疾病的下一个重大挑战，(2)堪萨斯州的一支强大的高级教员队伍正在这一领域工作，(3)堪萨斯州目前和未来对新教员的招聘计划强调对蛋白质结构和功能的研究。这种对蛋白质多学科研究的关注使我们能够利用大学最近在研究基础设施方面的投资，并以FTE、新的研究仪器和空间的形式为拟议的计划获得实质性的机构支持。根据科布雷主题的科学价值、与科布雷主题的相关性、从指导计划和核心实验室中受益的潜力，以及开发他们的项目以在未来成功竞争NIH拨款的可能性，六名教师被选为2-3年的支持对象。实现该计划目标的进展将由自学和内部和外部咨询委员会监督；后者还将审查新的初级教员为Cobre提供支持的提案和申请。