LSUHSC COBRE:HERPESVIRUS US GLYCOPROTEINS IN SEVERE INFLAMMATORY DISEASE

LSUHSC COBRE：严重炎症性疾病中的疱疹病毒和糖蛋白

• 批准号: 7171201
• 负责人: PATRICK F SMITH
• 金额: $ 23.7万
• 依托单位: LOUISIANA STATE UNIV HSC SHREVEPORT
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2006-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7171201
• 关键词: host organism interaction; virus cytopathogenic effect; virus genetics; virus infection mechanism; virus load

DESCRIPTION (provided by applicant): The purpose of this proposal submitted under the NIH IDEA Program is to promote sustainable improvements in research competitiveness and infrastructure at the LSU Health Sciences Center (LSUHSC) by establishing the Center of Biomedical Research Excellence (COBRE): Center for Molecular and Tumor Virology. Four senior virologists working in molecular, tumor, and immunological virology will serve as mentors to five junior level faculty members (one to be recruited in Year 2) to enhance their competitiveness for national funding and to increase the productivity of their developing research programs. A detailed plan to mentor these junior investigators with well-defined criteria to assess the development and competitiveness of their research programs is presented. The plan stresses close interaction of the mentors and junior faculty investigators and will create a Cell Culture and Molecular Analysis Core Facility that will complement the state-of-the-art services of the LSUHSC Research Core Facilities. In addition, an External Advisory Committee comprised of internationally recognized virologists, four being members of the National Academy of Sciences, will serve as reviewers of the Center for Molecular and Tumor Virology to provide oversight and peer review of the ongoing research projects and to offer suggestions that would contribute to the excellence of the Center. The Center is multidisciplinary as the projects of the junior faculty P.l.s interface with ongoing research in the Depts. of Medicine (viral diseases) and Physiology (altered endothelium) and our Cancer (tumor virology) and Arthritis (inflammation) Centers and address the mechanisms of different disease states resulting from viral infection. These diseases include herpesvirus induced severe inflammatory disease, cytomegalovirus induced alterations in endothelial cells leading to cardiovascular disease, molecular pathogenesis of yellow fever, and the role of polyamine metabolism in Epstein Barr virus lymphomagenesis. The Center has a thematic scientific focus in that molecular approaches applied to models of these disease states seek to elucidate the varied means by which viral gene products alter the cell and orchestrate events that result in disease. All four P.I.s are well trained in molecular virology at the doctoral and postdoctoral levels and will be provided the space, resources, and released time to develop state-of-the-art research programs competitive for national funding.

描述（由申请人提供）： 根据NIH IDEA计划提交的这项提案的目的是通过建立生物医学研究卓越中心（COBRE）：分子和肿瘤病毒学中心，促进路易斯安那州立大学健康科学中心（LSUHSC）研究竞争力和基础设施的可持续改进。 四名在分子，肿瘤和免疫病毒学领域工作的高级病毒学家将担任五名初级教师的导师（其中一名将在第二年招聘），以提高他们对国家资金的竞争力，并提高他们开发研究项目的生产力。一个详细的计划，指导这些初级研究人员与定义明确的标准，以评估他们的研究项目的发展和竞争力。该计划强调导师和初级教师研究人员的密切互动，并将创建一个细胞培养和分子分析核心设施，以补充LSUHSC研究核心设施的最先进服务。此外，一个由国际公认的病毒学家组成的外部咨询委员会，其中四名是美国国家科学院的成员，将担任分子和肿瘤病毒学中心的审查员，对正在进行的研究项目进行监督和同行审查，并提出有助于该中心取得卓越成就的建议。该中心是多学科的初级教师P.L.s接口与正在进行的研究在部门的项目。医学（病毒性疾病）和生理学（改变内皮）和我们的癌症（肿瘤病毒学）和关节炎（炎症）中心，并解决由病毒感染引起的不同疾病状态的机制。这些疾病包括疱疹病毒诱导的严重炎症性疾病、巨细胞病毒诱导的导致心血管疾病的内皮细胞改变、黄热病的分子发病机制以及多胺代谢在Epstein巴尔病毒淋巴瘤形成中的作用。该中心有一个主题的科学重点，即应用于这些疾病状态模型的分子方法，旨在阐明病毒基因产物改变细胞和精心策划导致疾病的事件的各种手段。所有四名PI都在博士和博士后水平上接受了良好的分子病毒学培训，并将提供空间，资源和释放时间来开发最先进的研究项目，以竞争国家资金。