Organic Synthesis Reagents on Transition Metals

复杂分子中碳-碳键的合成对于构筑化合物是必不可少的 新的药剂。在过去的几年里，左翼化合反应已经成为一种新的 这类化合物的一般构造方法。这种转变的关键是 活性、高效和选择性的催化剂的可用性。在过去的几年里， 已经开发了一系列催化剂，它们在广泛的一系列催化剂存在的情况下表现出高活性 不受保护的官能团。进一步的应用将要求催化剂是对映体和 立体选择性，并将对高度官能化的烯烃进行复分解反应。在过去的几年里 在授权期内，在开发指导配体设计的模型方面取得了进展。在.期间 在下一个授权期，这个模型将被用来构建新的配体系统 对映体选择性交叉复分解，对于立体选择性(控制双键的E：Z比 在交叉复分解中形成)，并增加空间受阻的烯烃的反应活性 将制备新的N-杂环卡宾配体，这种配体不仅在 选择性烯烃歧化催化剂的制备，但将在催化剂设计中普遍使用。 这种催化剂的成功建造将为建造 生物活性分子。

The synthesis of carbon-carbon bonds in complex molecules is essential for the construction of new pharmaceutical agents. Over the past several years, llefin metathesis has become a new general method for the construction of such compounds. Key to this transformation is the availability of catalysts that are active, efficient and selective. Over the past several years, a family of catalysts has been developed that shows high activity in the presence of a wide array of unprotected functional groups. Further applications will require catalysts that are enantio and stereoselective and will carry out metathesis on highly functionalized olefins. During the last granting period, progress was made in the development of a model to direct ligand design. During the next granting period, this model will be used to construct new ligand systems for enantiselective cross metathesis, for the stereoselective (control the E:Z ratio of the double bonds formed) in cross metathesis and increase the reactivity of sterically hindered olefins A variety of new N-heterocyclic carbene ligands will be prepared that will not only have applications in the preparation of selective olefin metathesis catalysts but will be of general use in catalyst design. Successful construction of such catalysts will open efficient new routes to the construction of bioactive molecules.