Organic Synthesis Reagents on Transition Metals

过渡金属有机合成试剂

• 批准号: 7195019
• 负责人: ROBERT Howard GRUBBS
• 金额: $ 39.12万
• 依托单位: CALIFORNIA INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-10-01 至 2009-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7195019
• 关键词: Acrylamide; Acrylamides; Acrylates; Air; Alcohols; Aldehydes; Alkenes; Area; Binding; Carbon; Chemicals; Chemistry; Class; Complex; Condition; Coupling; Cycloparaffins; Development; Electrons; Exposure to; Facility Construction Funding Category; Family; Funding; Generations; Grant; High temperature of physical object; Investigation; Legal patent; Ligands; Literature; Methods; Modeling; Nature; Numbers; Object Attachment; Organic Synthesis; Paper; Pharmacologic Substance; Preparation; Publishing; Reaction; Reagent; Relative (related person); Reporting; Research; Research Personnel; Role; Route; Ruthenium; Scheme; Solvents; System; Transition Elements; United States National Institutes of Health; Vinyl Compounds; Water; acrylate; base; carbene; catalyst; design; diene; functional group; improved; interest; polymerization; programs; tool

DESCRIPTION (provided by applicant): The synthesis of carbon-carbon bonds in complex molecules is essential for the construction of new pharmaceutical agents. Over the past several years, olefin metathesis has become a new general method for the construction of such compounds. Key to this transformation is the availability of catalysts that are active, efficient and selective. Over the past several years, a family of catalysts has been developed that shows high activity in the presence of a wide array of unprotected functional groups. Further applications will require catalysts that are enantio and stereoselective and will carry out metathesis on highly functionalized olefins. During the last granting period, progress was made in the development of a model to direct ligand design. During the next granting period, this model will be used to construct new ligand systems for enantioselective cross metathesis, for the stereoselective (control the E:Z ratio of the double bonds formed) in cross metathesis and increase the reactivity of sterically hindered olefins. A variety of new N-heterocyclic carbene ligands will be prepared that will not only have applications in the preparation of selective olefin metathesis catalysts but will be of general use in catalyst design. Successful construction of such catalysts will open efficient new routes to the construction of bioactive molecules.

描述（由申请人提供）：复杂分子中碳碳键的合成对于构建新药剂剂至关重要。在过去的几年中，烯烃的分解已成为构建此类化合物的新一般方法。这种转换的关键是活跃，高效和选择性的催化剂的可用性。在过去的几年中，已经开发了一系列催化剂，该家族在存在各种不受保护的功能组的情况下显示出很高的活性。进一步的应用将需要具有对映体和立体选择性的催化剂，并将对高度功能化的烯烃进行元理解。在最后一个授予期间，在开发指导配体设计的模型中取得了进展。在下一个授予期间，该模型将用于构建用于对映选择性交叉分解的新配体系统，用于在交叉隔离中的立体选择性（控制形成的双键的E：z比率），并提高静置阻碍的烯烃的反应性。将准备各种新的N-杂环碳纤维配体，不仅可以在准备选择性烯烃分解催化剂方面进行应用，而且将在催化剂设计中进行一般用途。成功构建此类催化剂将为生物活性分子的构建提供有效的新途径。