Synthetic antimicrobials based on natural toxins

基于天然毒素的合成抗菌剂

• 批准号: 2879076
• 金额: --
• 依托单位: Durham University
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2879076
• 关键词: Synthetic; antimicrobials; based; natural; toxins

Tuberculosis remains the deadliest bacterial disease on the planet, killing around 1.5 million people each year. It can be treated, but antibiotic resistance is increasing. Mycobacterium tuberculosis can survive antibiotic treatment by slowing down its growth using naturally occurring toxins made inside tuberculosis cells. Some of these toxins target the essential process of untangling DNA after it replicates. We have characterised the enzyme that performs the activity of separating new DNA chromosomes, and have shown that toxins inhibit its action. Now we aim to generate atomic resolution models of toxin activity, so we can generate antimicrobial mimics for treating infections.

结核病仍然是地球上最致命的细菌性疾病，每年导致约 150 万人死亡。它可以被治疗，但抗生素耐药性正在增加。结核分枝杆菌可以通过使用结核细胞内自然产生的毒素来减缓其生长，从而在抗生素治疗中存活下来。其中一些毒素针对 DNA 复制后解开缠结的基本过程。我们已经表征了执行分离新 DNA 染色体活性的酶，并表明毒素会抑制其作用。现在我们的目标是生成毒素活性的原子分辨率模型，以便我们可以生成用于治疗感染的抗菌模拟物。