Characterization and optimization of new Silver based Antimicrobials

新型银基抗菌剂的表征和优化

• 批准号: 543393-2019
• 负责人: Bohle, David
• 金额: $ 1.82万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=680346
• 关键词: Characterization; optimization; new; Silver; based

This proposed research program is between scientists at Exciton Technologies Inc. and McGill's department of chemistry. Exiton's scientists have devised a new class of silver based antimicrobial agents to be used in wound treatment. In an effort to better characterize these new derivatives a new series of silver(III) periodate complexes will be studied and their formulations optimized for more sustained and efficient antimicrobial activity. The work at McGill will include a range of advanced techniques including. X-ray crystallography, Raman Spectroscopy, and solid state NMR. With these methods the solid state structures and solution chemistry of these formulations will be determined. These properties will then be used in an iterative fashion to improve their antimicrobial efficiency and lifetimes. In all, this work is expected to improve on the product of a dynamic Canadian company which will be useful in many clinical and hospital setting for advanced wound treatment.

这项拟议中的研究计划是由激子技术公司的科学家们共同完成的。和麦吉尔的化学系 Exiton的科学家们已经设计出一种新的银基抗菌剂，用于伤口治疗。 为了更好地表征这些新衍生物，将研究一系列新的高银（III）络合物，并优化其配方以获得更持久和有效的抗微生物活性。麦吉尔大学的工作将包括一系列先进的技术，包括。 X射线晶体学、拉曼光谱学和固态NMR。 通过这些方法，将确定这些制剂的固态结构和溶液化学。 然后，这些特性将以迭代的方式使用，以提高其抗菌效率和寿命。 总之，这项工作预计将改善一个充满活力的加拿大公司的产品，这将是有用的，在许多临床和医院设置为先进的伤口治疗。