AUSTRALIAN CHILDREN OF ALCOHOLIC FEMALE TWINS

澳大利亚酗酒女性双胞胎的孩子

• 批准号: 7072847
• 负责人: WENDY S SLUTSKE
• 金额: $ 24万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-06-01 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7072847
• 关键词: Australia; adolescence (12-20); alcoholism /alcohol abuse; attention deficit disorder; behavioral /social science research tag; behavioral genetics; child psychology; clinical research; conduct disorder; early experience; family genetics; gene environment interaction; genetic susceptibility; human subject; interview; longitudinal human study; maternal behavior; mental disorder diagnosis; mental health epidemiology; middle childhood (6-11); mother child interaction; oppositional defiant disorder; twin /multiplet; young adult human (21-34)

The goal of this competing continuation request is to examine the role of genetic and family environmental influences, and their interaction, in the development and course of alcohol use disorders (AUD). This is to be achieved using a research strategy that incorporates 3 novel features: (a) use of the infrequently implemented yet powerful children of twins (COT) design involving twins who are concordant or discordant for-AUD as well as control pairs; (b) assessment of children of alcoholic mothers; (c) use of a prospective design which allows for the description of offspring development from preadolescence through the late twenties. The COT design is particularly well suited for studying environmental variables associated with maternal alcoholism in that statistical controls for genetic influences are embedded within the design, providing the opportunity to isolate environmental variables that are etiologically relevant to the development of alcohol problems. It is also well suited for detecting the contribution of genetic transmission to the association between AUDs in parents, and other disorders in offspring (e.g. Attention Deficit Hyperactivity Disorder, ADHD), as well as potential genotype x environment interaction effects. The assessment of twin mothers will fill an important research need in the field and will allow for comparisons with our MARC-affiliated studies involving the same design but based on twin fathers. Finally, our longitudinal, prospective design will allow us to make much stronger statements concerning the development of AUD than would be possible using only retrospective data from a cross-sectional study. During the renewal period, we will continue to expand our recruitment efforts, broadening our eligibility criteria to include mothers with offspring as young as 7 years. In so doing we will be able to confirm or disconfirm our emerging data based on retrospective reports of twin mothers about their adolescent and young adult offspring on disorders with early childhood onset (ADHD, Oppositional Defiant Disorder [ODD], conduct disorder [CD]). We will continue follow-up assessments by maternal interview (offspring aged 9-18) and offspring interview (aged 11-30). By the end of the renewal period, samples will be sufficiently large so that complex cross-sectional and longitudinal analyses will be firmly based.

这个相互竞争的延续请求的目标是研究遗传和家庭的作用 在酒精使用障碍(AUD)的发展和过程中，环境影响及其相互作用。这是通过一项结合了3个新特点的研究战略来实现的：(A)使用不经常实施但功能强大的双胞胎设计，包括双胞胎-AUD和对照对的协调或不协调的双胞胎；(B)评估酗酒母亲的子女；(C)使用前瞻性设计，描述从青春期前到近30岁的后代发育。COT设计特别适合于研究与母亲酗酒有关的环境变量，因为设计中嵌入了对遗传影响的统计控制，从而提供了隔离与酒精问题发展的病因学相关的环境变量的机会。它还非常适合于检测遗传传播对父母的AUD和后代的其他疾病(如注意力缺陷多动障碍，ADHD)之间的关联的贡献，以及潜在的基因x环境交互影响。对双胞胎母亲的评估将填补该领域的一个重要研究需求，并将允许与我们的MARC附属研究进行比较，这些研究涉及相同的设计，但基于双胞胎父亲。最后，我们的纵向、前瞻性设计将使我们 仅使用一项横断面研究的回溯性数据，对AUD的发展做出比可能的更有力的陈述。在续期期间，我们将继续扩大招聘工作，扩大我们的资格标准，将子女年仅7岁的母亲包括在内。通过这样做，我们将能够基于双胞胎母亲关于她们青春期和年轻成年子女关于儿童早期发病障碍(ADHD，对抗性违抗障碍[ODD]，品行障碍[CD])的回顾报告，确认或否认我们正在出现的数据。我们将继续通过母亲访谈(9-18岁的子女)和子女访谈(11-30岁)进行后续评估。到续签结束时 在此期间，样本量将足够大，以便复杂的横断面和纵向分析具有坚实的基础。