MSKCC Research Center for Botanical Immunomodulators

纪念斯隆-凯特琳癌症中心的植物研究中心将由一个 由资深科学家组成的多学科协作团队，在每个领域都拥有实验室和临床专业知识，以实现我们的目标。该中心将对之前描述的具有免疫调节活性的五种植物补充剂(紫锥菊、黄芪、姜黄、美塔克和TJ-48草本制剂)进行系统研究，解决植物补充剂的组成、作用机制、临床前模型的开发以及转化为临床应用。该中心汇集了基础科学和临床免疫学、肿瘤学、传染病、植物学、有机化学和补充医学的领军人物，在四个项目和两个核心。利文斯顿的项目将研究植物药物对免疫系统传入臂的影响，以确定植物药物如何调节抗原识别和启动免疫反应。张的项目将解决对传出手臂的影响 确定植物类药物如何增强效应细胞活性和分子靶点。Pamer的项目将研究这两种影响的整合，通过宿主对感染的反应的动物模型来确定它们在多间隔免疫系统中的最终结果。卡西莱斯的项目将解决人类使用的基本问题：生物标记物和安全。行政核心将协调中心内的研究活动，整合研究成果，并促进研究和咨询小组之间的信息交流。植物学核心将使用基因组和化学技术鉴定和标准化研究植物，分离植物提取物以表征成分，并分离活性成分以供进一步研究。它将有助于研究植物药物的制备，以达到FDA级别的质量标准。总而言之，这些项目涵盖了植物免疫调节剂研究的多个维度，涉及成分、机制、标准化和人类生物标记物，以及从分子和细胞研究到动物和人类研究的宿主免疫反应的全方位。我们的目标是推进具有代表性的植物免疫调节剂的科学和知识库，开发植物学研究的模型实验系统，并产生基于证据的信息来指导人类使用它们。

The Botanical Research Center at Memorial Sloan-Kettering Cancer Center will consist of a multidisciplinary collaborative team of senior scientists with laboratory and clinical expertise in each area required to reach our goal. The Center will pursue systematic investigation of five botanical supplements with previously described immunomodulatory activities (Echinacea, Astragalus, Turmeric, Maitake, and TJ-48 herbal formulation), addressing composition of the botanicals, mechanism of action, development of preclinical models, and translation to clinical application. The Center brings together leaders in basic science and clinical immunology, oncology, infectious diseases, botanicals, organic chemistry, and complementary medicine in four projects and two cores. Project by Livingston will study the effect of botanicals on the afferent arm of the immune system to determine how botanicals modulate antigen recognition and initiate immune response. Project by Cheung will address impact on the efferent arm to determine how botanicals enhance effector cell activity and molecular targets. Project by Pamer will investigate the integration of these two effects, determining their end result in the multi-compartment immune system via animal models of host response against infection. Project by Cassileth will address issues essential to human use: biomarkers and safety. The Administrative Core will coordinate research activities within the center, integrate research findings, and facilitate information exchange among research and advisory groups. The Botanical Core will authenticate and standardize study botanicals using genomic and chemical technology, fractionate botanical extracts to characterize constituents, and isolate active constituents for further study. It will aid preparation of study botanicals to meet FDA-level quality standards. Together, these projects encompass multiple dimensions of botanical immunomodulator research, addressing composition, mechanism, standardization and human biomarkers, and the full spectrum of host immune response, from molecular and cellular studies to animal and human research. We aim to advance the science and knowledge base of representative botanical immunomodulators, develop model experimental systems for botanical research, and generate evidence-based information to guide their human use.