NATURAL HISTORY OF AMYLOID DEPOSITION IN FAMILIAL AD

家族性 AD 中淀粉样蛋白沉积的自然史

• 批准号: 6933328
• 负责人: WILLIAM E KLUNK
• 金额: $ 18.56万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6933328
• 关键词: Alzheimer' s disease; amyloid proteins; autosomal dominant trait; bioimaging /biomedical imaging; brain imaging /visualization /scanning; clinical research; early diagnosis; family genetics; gene mutation; genetic carriers; genetic disorder; genetic susceptibility; human subject; longitudinal human study; pathologic process; positron emission tomography; protein localization

Our team at the University of Pittsburgh has recently developed a promising, non-invasive, in vivo PET tracer for use in imaging amyloid deposition in living humans. The tracer has become commonly known as Pittsburgh Compound-B (PIB). This Project will exploit this new technology by conducting an exploratory analysis with the overall goals of documenting pre-symptomatic amyloid deposition in living subjects destined to develop Alzheimer's disease (AD) and then determining the natural history of amyloid deposition in these subjects. In order to accomplish these goals within the constraints of an ADRC project, we will focus on early-onset, autosomal dominant, familial AD (eFAD) kindreds. In particular, we will focus on known mutation carriers who have not yet developed symptoms (as determined by the ADRC Clinical Core). We also will study four symptomatic eFAD subjects and four age-matched members of the kindreds who do not carry the mutation (as controls). The PEB retention in these latter groups will be compared to typical sporadic AD cases and typical controls to exclude the possibility of unusual findings in these eFAD families. We plan to identify and follow at least four mutation carriers with no symptoms of dementia who show evidence of amyloid deposition on the initial scan (i.e., increased PIB retention) at yearly intervals to document the natural history of amyloid deposition in these subjects who are on a relatively predictable trajectory toward clinical AD. We also plan to follow at least four other asymptomatic mutation carriers, who show no evidence of amyloid deposition at baseline, at two-year intervals, allowing the possibility of detecting the very onset of amyloid deposition. Although the number of subjects is necessarily small (due to the scarcity of the mutation carriers and budget constraints), the predictable nature of the future clinical course (determined by genotype) will likely allow us to document, for the first time, pre-symptomatic amyloid deposition in a subject known to be on a path toward clinical AD. The follow-up studies proposed will likely provide important information regarding the natural history of amyloid deposition in eFAD subjects. This data is necessary to deepen our understanding of the pathophysiology of AD and to form a foundation for the design and interpretation of anti-amyloid drug trials.

我们匹兹堡大学的团队最近开发了一种很有前途的、无创的、体内PET示踪剂，用于成像活体淀粉样蛋白沉积。这种示踪剂通常被称为匹兹堡化合物b （PIB）。本项目将利用这项新技术进行探索性分析，其总体目标是记录注定要发展为阿尔茨海默病（AD）的活着的受试者的症状前淀粉样蛋白沉积，然后确定这些受试者的淀粉样蛋白沉积的自然史。为了在ADRC项目的限制下实现这些目标，我们将专注于早期发病，