Program Project in Models of Breast Cancer

乳腺癌模型项目

• 批准号: 7124344
• 负责人: LARRY NORTON
• 金额: $ 268.6万
• 依托单位: SLOAN-KETTERING INST CAN RESEARCH
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7124344
• 关键词: biological models; breast neoplasms; neoplastic process

DESCRIPTION (provided by applicant): This Program Project Grant application presents a coordinated, interactive group of laboratory projects and a core resource, united by a concern with breast cancer and by the use of mouse models of the human disease. It achieves scientific synergy and an economy of effort by the sharing of existing strains, the collaborative development of new strains (e.g., bi-transgenic mice), the configuration and use of a new core facility for the imaging of mouse tumors, the cooperative discovery and selective use of new methods for the characterization of genotypes and phenotypes, and the design, conduct, and analysis of therapeutic trials in laboratory animals using drugs and other reagents developed within the P01. Because active cancer clinicians are intrinsically involved in these efforts, the knowledge gained In our laboratories will have a direct and substantial impact on clinical thinking, education, and research. Project 1, under Dr. Harold Varmus, examines the determinants of tumor progression in mouse models of human breast cancer and related models of ovarian and islet cell neoplasia. Project 2, under Dr. Joan Massague, concerns the TGF-beta eta signaling pathway. Project 3, under Dr. Neal Rosen, develops the ansamycin antibiotics as therapeutic agents and reagents for the study of cancer biology. Project 4, under Drs. Maria Jasin and Mary Ellen Moynahan, explores the consequences of defective homologous repair incurred through BRCA1 and BRCA2 mutations. Project 5, underDr. Robert Benezra, concerns the Id genes and their relation to neoangiogenesis. An Imaging Core, under Drs. Steven Larson and Juri Tjuvajev, supplies advanced imaging technology to the Projects. Dr. Larry Norton serves as Principal Investigator, Dr. Joan Massague as Co-Principal Investigator, and Dr. Agnes Viale as Coordinator of Molecular Array Technologies.

描述(由申请人提供)： 该计划项目赠款申请提供了一组协调的、互动的实验室项目和核心资源，通过对乳腺癌的关注和对人类疾病的老鼠模型的使用而结合在一起。它通过共享现有菌株、合作开发新的菌株(例如，双转基因小鼠)、配置和使用用于小鼠肿瘤成像的新核心设施、合作发现和选择性使用表征基因和表型的新方法，以及使用在P01中开发的药物和其他试剂对实验室动物进行的治疗试验的设计、实施和分析，实现了科学的协同效应和工作的经济性。由于活跃的癌症临床医生本质上参与了这些努力，我们实验室获得的知识将对临床思维、教育和研究产生直接和实质性的影响。在Harold Varmus博士的领导下，项目1检查了人类乳腺癌的小鼠模型以及卵巢和胰岛细胞肿瘤的相关模型中肿瘤进展的决定因素。项目2，在Joan Massague博士的指导下，涉及转化生长因子-βETA信号通路。在尼尔·罗森博士的领导下，项目3开发了安沙霉素抗生素，作为癌症生物学研究的治疗剂和试剂。项目4，在Maria Jasin和Mary Ellen Moynahan博士的带领下，探索了由BRCA1和BRCA2突变引起的缺陷同源修复的后果。项目5，在Dr。Robert Benezra，关注ID基因及其与新血管生成的关系。由史蒂文·拉森和尤里·朱瓦耶夫博士领导的成像核心公司为这些项目提供先进的成像技术。拉里·诺顿博士担任首席研究员，琼·马萨格博士担任联合首席研究员，Agnes Viale博士担任分子阵列技术协调员。