Leadership Core

领导核心

• 批准号: 7438490
• 负责人: LARRY NORTON
• 金额: $ 42.53万
• 依托单位: SLOAN-KETTERING INST CAN RESEARCH
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-05 至 2013-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7438490
• 关键词: Appointment; Basic Cancer Research; Biological Sciences; Budgets; Chemicals; Collaborations; Genotype; Image; Individual; Institution; Laboratories; Leadership; Medicine; Memorial Sloan-Kettering Cancer Center; Methods; Molecular; Mus; Pathology; Performance; Phenotype; Preparation; Process; Purpose; Resources; Scientist; Technology; Transgenic Mice; concept; design; molecular array; programs; size

The Leadership Core is a resource comprised of the individuals who will provide two essential components of the P01. The first is the central organizational, operational, and oversight coordination. The second is the planning, preparation, coordination, and performance of the statistical analyses, including the interpretation of molecular microarrays. The Leadership Core includes the Program Director, the Co-Program Director, the Coordinators of Molecular Array Technology and Inter-Project Integration, the Biostatistician, and Liaisons to the Departments of Medicine and Pathology. A major purpose of this core is to promote the integration of the five projects and the Imaging Core. It must be emphasized that the projects are being conducted in well-established, highly-productive laboratories that are led by some of the leaders in the field of cancer research and basic biological science. Hence, the prime form of cooperation/collaboration among the projects consists of the exchange of concepts, bio-constructs including transgenic mice, unique chemicals, imaging expertise, methods for the characterization of genotypes and phenotypes, and constructive deliberation concerning the design, conduct, and analysis of mouse studies. In an institution the size and breadth of MSKCC it cannot be assumed that interactions happen spontaneously, so it takes concerted effort¿such as the P01¿to make them happen. We have enjoyed considerable benefit in this regard from our monthly meetings and through the efforts of our bio-statistician (Dr. Olshen), but we intend to take the process a step further by the appointment of Dr. Mary Ellen Moynahan¿an accomplished scientist (Project 4) and clinician¿as Coordinator of Inter-Project Integration. Her specific activities are listed in the budget justification for this core and her qualifications are described below.

领导核心是一种由个人组成的资源，他们将提供两个 P01的基本组成部分。第一个是中央组织、业务和 监督协调。二是规划、准备、协调， 统计分析的性能，包括分子解释 微阵列领导核心包括项目总监、联合项目 主任，分子阵列技术和项目间整合协调员， 生物统计学家，以及与医学和病理学部门的联络员。 这一核心的一个主要目的是促进五个项目的整合， 成像核心必须强调的是，这些项目是在 由一些知名人士领导的成熟、高效的实验室 癌症研究和基础生物科学领域的领导者。所以 项目间合作/协作的主要形式包括 概念交流，生物构建，包括转基因小鼠，独特的 化学品，成像专业知识，基因型表征方法， 表型，以及关于设计，行为和 小鼠研究分析。在一个机构的规模和广度的MSKCC它 不能假设相互作用是自发发生的，所以需要协调一致的 #21001;的努力，使其成为现实。我们已经享受了相当多的 在这方面，通过我们的每月会议和我们的努力， 生物统计学家（Olshen博士），但我们打算采取的过程更进一步， 任命玛丽埃伦·莫伊纳汉博士为杰出的科学家（项目 4)和临床医生作为项目间整合协调员。她的具体活动 在该核心的预算理由中列出，她的资格是 如下所述