Leadership Core

领导核心是由个人组成的资源，他们将提供两个 P01的基本组件。第一个是中央组织、运营和 监督协调。二是规划、准备、协调和 统计分析的表现，包括对分子的解释 微阵列。领导核心包括项目总监、合作项目 主任，分子阵列技术和项目间集成协调人， 生物统计师，以及与内科和病理学系的联系。 这一核心的一大目的是促进五个项目和 成像核心。必须强调的是，这些项目是在 久负盛名的高效实验室，由一些 癌症研究和基础生物科学领域的领军人物。因此， 项目之间合作/协作的主要形式包括 概念交流，包括转基因小鼠在内的生物结构，独一无二 化学品、成像专门知识、确定基因类型的方法和 表型，以及关于设计、实施和 小鼠研究的分析。在MSKCC的规模和广度上 不能假设交互是自发发生的，因此需要协调 为实现这些目标所作的努力，如P01。我们已经享受到了相当大的 在这方面受益于我们每月的会议，并通过我们的努力 生物统计学家(奥尔申博士)，但我们打算通过以下方式进一步推进这一过程 任命Mary Ellen Moynahan博士为一位有成就的科学家(项目 4)和临床医生担任项目间整合协调员。她的具体活动 都列在这个核心的预算理由中，她的资格是 如下所述。

The Leadership Core is a resource comprised of the individuals who will provide two essential components of the P01. The first is the central organizational, operational, and oversight coordination. The second is the planning, preparation, coordination, and performance of the statistical analyses, including the interpretation of molecular microarrays. The Leadership Core includes the Program Director, the Co-Program Director, the Coordinators of Molecular Array Technology and Inter-Project Integration, the Biostatistician, and Liaisons to the Departments of Medicine and Pathology. A major purpose of this core is to promote the integration of the five projects and the Imaging Core. It must be emphasized that the projects are being conducted in well-established, highly-productive laboratories that are led by some of the leaders in the field of cancer research and basic biological science. Hence, the prime form of cooperation/collaboration among the projects consists of the exchange of concepts, bio-constructs including transgenic mice, unique chemicals, imaging expertise, methods for the characterization of genotypes and phenotypes, and constructive deliberation concerning the design, conduct, and analysis of mouse studies. In an institution the size and breadth of MSKCC it cannot be assumed that interactions happen spontaneously, so it takes concerted effort¿such as the P01¿to make them happen. We have enjoyed considerable benefit in this regard from our monthly meetings and through the efforts of our bio-statistician (Dr. Olshen), but we intend to take the process a step further by the appointment of Dr. Mary Ellen Moynahan¿an accomplished scientist (Project 4) and clinician¿as Coordinator of Inter-Project Integration. Her specific activities are listed in the budget justification for this core and her qualifications are described below.