Cancers in Older Minority Populations: Caribbean Americ*

描述（由申请人提供）：在过去的四年中，长岛大学布鲁克林校区（LIU）和哥伦比亚大学赫伯特·欧文综合癌症中心（HICCC）的研究人员之间建立了紧密的联系。已经产生了几个联合赠款和项目，总额超过200万美元，还有两个提案悬而未决。此次合作的基础是NCI （CA91372）的P20。这些研究主要集中在布鲁克林和曼哈顿北部的非裔加勒比移民人口（包括多米尼加人、海地人和说英语的加勒比人）和美国出生的非裔美国人和欧洲美国人之间的差异。这项研究包括可能与癌症相关的健康差异有关的行为、文化、生活方式和生物遗传差异。在这一申请中，我们建议在现有伙伴关系的基础上，将其作为一个平台，对同样的问题进行更广泛、更全面的研究。这种伙伴关系将把两个机构融合在一起，重点是把它们互补的优势结合起来。刘的PI是一位著名的心理学家，对布鲁克林的这些人群有着广泛的行为和调查研究经验。哥伦比亚大学的PI是一位医学肿瘤学家和流行病学家，在癌症预防和控制研究方面有着良好的记录，在MCCC中处于领导地位。HICCC将提供其核心设施，特别是生物统计学核心，而LlU将提供其在调查和行为研究方面的专业知识。这两个机构的邻近将允许两个中心的个人参加频繁的研讨会和讲习班，以及每个中心的年度静修。两所学校的学生和教师也将有机会参加各自机构的课程和讲座。同样重要的是，旨在为少数族裔学生和教师提供癌症研究经验的项目，刘的学生有机会获得哥伦比亚大学项目的录取和奖学金，刘的一名少数族裔博士将在哥伦比亚大学获得T32博士后。2个项目和4个试点是U54计划。每年将为下一年的资助进行竞争；提案将由外部审查员审查，正如我们在P20中成功进行的那样。正在进行的/提议的项目/试点将在每月一次的研讨会上进行讨论，统计学家、数据管理学家和方法学家将参加该研讨会，提供建设性的讨论。西印度群岛大学（UWI）的一名代表将参加EAB年度会议，并通过视频会议，参加每季度的内部指导委员会会议，讨论双重地点（布鲁克林/加勒比）项目的长期可能性。这种伙伴关系具有独特的研究对象，成功的现有关系，并强调人口科学研究。

DESCRIPTION (provided by applicant): Strong ties have developed between investigators at Long Island University's Brooklyn campus (LIU) and Columbia University's Herbert Irving Comprehensive Cancer Center (HICCC) over the past four years. Several joint grants and projects have resulted, totaling over $2 million, with two proposals pending. Anchoring this collaboration has been a P20 from NCI (CA91372). These research efforts have focused on differences among African Caribbean immigrant populations in Brooklyn and North Manhattan (including Dominican, Haitian, and English-speaking Caribbeans) and US-born African Americans and European Americans. The research includes behavioral, cultural, lifestyle, and biological genetic differences that may relate to cancer-related health disparities. In this application, we propose to build upon the existing partnership and use it as a platform for a broader, more comprehensive study of the same issues. This partnership would meld the two institutions, with an emphasis on bringing together their complementary strengths. The PI at LIU is a well-known psychologist with extensive behavioral and survey research experience with these populations in Brooklyn. The PI at Columbia is a medical oncologist and epidemiologist with a strong record in cancer prevention and control research and a leadership position in the MCCC. HICCC will provide access to its core facilities, especially the Biostatistics Core, while LlU will provide its expertise in survey and behavioral research. The proximity of the two institutions will permit frequent seminars and workshops attended by individuals from both centers, as well as an annual retreat at each center. Students and faculty at each will also have access to courses and lectures at each of the institutions. Equally important will be programs designed to provide experience for minority students and faculty in cancer research, with the opportunity for students from LIU to obtain admissions and fellowships to Columbia programs, illustrated by a minority predoc from LIU who will have a T32 postdoc at Columbia. Two projects and four pilots are U54 program. There will be an annual competition for funding for the following year; proposals will be reviewed by external reviewers, as was successfully conducted in our P20. Ongoing/proposed projects/pilots will be I discussed at a monthly workshop alternating between campuses at which statisticians, data management, and methodologists will attend to provide constructive discussion. A representative from the University of West Indies (UWI) will attend annual EAB meetings and, via videoconference, quarterly internal steering committee meetings with long-term possibilities for dual site (Brooklyn/Caribbean) projects. This partnership has a unique study population, a successful existing relationship, and an emphasis on population science research.