Cancers in Older Minority Populations: Caribbean Americ*

描述(由申请人提供)：在过去的四年里，长岛大学布鲁克林校区(刘)和哥伦比亚大学赫伯特·欧文综合癌症中心(HICCC)的研究人员之间建立了牢固的联系。已经产生了几个联合赠款和项目，总额超过200万美元，还有两项提案待决。来自NCI的P20(CA91372)一直支撑着这一协作。这些研究的重点是布鲁克林和曼哈顿北部的非洲加勒比移民人口(包括多米尼加人、海地人和说英语的加勒比海人)以及在美国出生的非洲裔美国人和欧洲裔美国人之间的差异。这项研究包括行为、文化、生活方式和生物遗传差异，这些差异可能与癌症相关的健康差异有关。在这一申请中，我们建议在现有伙伴关系的基础上，将其作为更广泛、更全面地研究相同问题的平台。这种伙伴关系将使这两个机构融合在一起，重点是将它们的互补优势结合在一起。刘的PI是一位著名的心理学家，对布鲁克林的这些人群有着丰富的行为和调查研究经验。哥伦比亚大学的PI是一名内科肿瘤学家和流行病学家，在癌症预防和控制研究方面有着良好的记录，并在MCCC担任领导职务。HICCC将提供对其核心设施的访问，特别是生物统计核心，而LLU将提供其在调查和行为研究方面的专业知识。这两个中心距离很近，这将使两个中心的个人经常参加研讨会和研讨会，并在每个中心举行年度务虚会。每所学校的学生和教职员工也将有机会参加每所学校的课程和讲座。同样重要的是，旨在为少数族裔学生和教师提供癌症研究经验的项目，让来自刘的学生有机会获得哥伦比亚大学项目的录取和奖学金，刘的一名少数民族博士后将在哥伦比亚大学获得T32博士后学位。两个项目和四个试点是U54计划。将每年为下一年的资金竞争；提案将由外部审查员审查，正如我们在P20中成功进行的那样。正在进行的/拟议的项目/试点将在每月一次的研讨会上讨论，该研讨会在各校园之间轮流举行，统计学家、数据管理人员和方法学家将参加研讨会，以提供建设性的讨论。西印度群岛大学(UWI)的一名代表将出席EAB年度会议，并通过视频会议参加季度内部指导委员会会议，讨论两个地点(布鲁克林/加勒比海)项目的长期可能性。这一伙伴关系有一个独特的研究群体，一个成功的现有关系，并强调人口科学研究。

DESCRIPTION (provided by applicant): Strong ties have developed between investigators at Long Island University's Brooklyn campus (LIU) and Columbia University's Herbert Irving Comprehensive Cancer Center (HICCC) over the past four years. Several joint grants and projects have resulted, totaling over $2 million, with two proposals pending. Anchoring this collaboration has been a P20 from NCI (CA91372). These research efforts have focused on differences among African Caribbean immigrant populations in Brooklyn and North Manhattan (including Dominican, Haitian, and English-speaking Caribbeans) and US-born African Americans and European Americans. The research includes behavioral, cultural, lifestyle, and biological genetic differences that may relate to cancer-related health disparities. In this application, we propose to build upon the existing partnership and use it as a platform for a broader, more comprehensive study of the same issues. This partnership would meld the two institutions, with an emphasis on bringing together their complementary strengths. The PI at LIU is a well-known psychologist with extensive behavioral and survey research experience with these populations in Brooklyn. The PI at Columbia is a medical oncologist and epidemiologist with a strong record in cancer prevention and control research and a leadership position in the MCCC. HICCC will provide access to its core facilities, especially the Biostatistics Core, while LlU will provide its expertise in survey and behavioral research. The proximity of the two institutions will permit frequent seminars and workshops attended by individuals from both centers, as well as an annual retreat at each center. Students and faculty at each will also have access to courses and lectures at each of the institutions. Equally important will be programs designed to provide experience for minority students and faculty in cancer research, with the opportunity for students from LIU to obtain admissions and fellowships to Columbia programs, illustrated by a minority predoc from LIU who will have a T32 postdoc at Columbia. Two projects and four pilots are U54 program. There will be an annual competition for funding for the following year; proposals will be reviewed by external reviewers, as was successfully conducted in our P20. Ongoing/proposed projects/pilots will be I discussed at a monthly workshop alternating between campuses at which statisticians, data management, and methodologists will attend to provide constructive discussion. A representative from the University of West Indies (UWI) will attend annual EAB meetings and, via videoconference, quarterly internal steering committee meetings with long-term possibilities for dual site (Brooklyn/Caribbean) projects. This partnership has a unique study population, a successful existing relationship, and an emphasis on population science research.