Emotion and Cognition on Gene, Cell, and Systems Levels

基因、细胞和系统层面的情感和认知

• 批准号: 6834129
• 负责人: Joachim Spiess
• 金额: $ 196.69万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-30 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6834129
• 关键词: clinical research; cooperative study; corticotropin releasing factor; emotions; interdisciplinary collaboration; minority institution research support; neurosciences

DESCRIPTION (provided by applicant): This application seeks continuation funding for a Specialized Neuroscience Research Program (SNRP) at this minority serving institution. Whereas the goals of the SNRP during the previous funding period were to increase Neuroscience research capacity on this campus, the present application seeks to build on that previous success by establishing a focused and coordinated, team research, program. This program will address "Emotion and cognition on gene, cell and systems levels", with a primary focus on the effects of stress and anxiety on emotion and cognition, recognizing that increased understanding of these interactions is of major importance to human health. The proposal brings together a wide range of interdisciplinary experience (including psychiatry, psychology, molecular biology, neuroimaging, genetics, neuroanatomy, neuropharmacology, electrophysiology, biochemistry and animal behavior) to address four specific aspects of this overall problem, utilizing both human subjects and animal models (Aim 1). Nevertheless, the demands of team research will be balanced by the need to provide a carefully constructed program that fosters individual academic development of SNRP participants at all levels (Aim 2). Additionally, this proposal will attempt to demonstrate the effectiveness of team research in the biomedical sciences, such as to stimulate additional team research efforts in this area (Aim 3). Finally, this proposal seeks to generate a strong and cohesive academic and research training "center" for the Neurosciences at this University (Aim 4), such that this University will become known over time as a national and international resource for Neuroscience research and training. Titles of the specific projects are: Stress-induced CRF actions on fear and anxiety; Stress effects on amygdalar CRF and emotion; Methamphetamine psychosis: a model in man and mouse; CRF systems and defensive behavior. The proposal provides a Peptide and DNA Technology Core to support these projects.

描述（由申请人提供）： 本申请旨在继续资助这个少数民族服务机构的专业神经科学研究计划（SNRP）。鉴于SNRP在上一个资助期间的目标是提高该校区的神经科学研究能力，本申请旨在通过建立一个集中和协调的团队研究计划来建立以前的成功。该计划将解决“基因，细胞和系统水平上的情感和认知”，主要关注压力和焦虑对情感和认知的影响，认识到增加对这些相互作用的理解对人类健康至关重要。 该提案汇集了广泛的跨学科经验（包括精神病学，心理学，分子生物学，神经影像学，遗传学，神经解剖学，神经药理学，电生理学，生物化学和动物行为学），以解决这一总体问题的四个具体方面，利用人类受试者和动物模型（目标1）。然而，团队研究的需求将通过提供精心构建的计划来平衡，该计划旨在促进SNRP参与者在各个层面的个人学术发展（目标2）。此外，该提案将试图证明团队研究在生物医学科学中的有效性，例如鼓励在该领域进行更多的团队研究（目标3）。最后，该提案旨在为该大学的神经科学建立一个强大而有凝聚力的学术和研究培训“中心”（目标4），以便该大学随着时间的推移将成为神经科学研究和培训的国家和国际资源。具体项目的标题是：压力引起的CRF对恐惧和焦虑的作用;压力对杏仁CRF和情绪的影响;甲基苯丙胺精神病：人和小鼠模型; CRF系统和防御行为。该提案提供了一个肽和DNA技术核心来支持这些项目。