A first-responder EEG device for seizure management in a nerve gas attack

描述（由申请人提供）：神经毒气被许多人视为穷人的原子弹。正如1995年3月东京地铁袭击事件所表明的那样，它们可以被用来在人口密集的密闭空间造成大规模伤亡。医疗管理主要包括将病人转移到一个开放的空间。给予阿托品，并用苯二氮卓类药物滴定抽搐以终止癫痫发作（de Jong 2003）。重要的是，如果抽搐活动停止，它可能代表神经毒剂引起的麻痹，而不是癫痫活动的终止，需要进行脑电图监测（Hostege等，1997）。该项目开发了一种第一反应EEG设备，用于在神经毒气袭击事件中进行癫痫发作管理。Persyst Reveal软件的修改版本将用于解决稳态癫痫检测问题。生物信号集团将开发一种无线脑电图放大器。计算平台将基于现成的袖珍个人电脑。我们的目标是使该设备无需事先指示即可使用。预计神经毒气袭击现场将造成大量人员伤亡。该装置将大大减少神经系统并发症——包括不可逆的脑损伤和死亡——由于长时间的癫痫发作，否则可能由于神经毒气的麻痹作用而无法诊断。

DESCRIPTION (provided by applicant): Nerve gas agents are seen by many as the poor man's atom bomb. As demonstrated in the March 1995 Tokyo subway attack, they can be used to inflict mass casualties in densely populated, confined air spaces. Medical management consists primarily of removing patients to an open air space. Atropine is administered and convulsions are titrated with benzodiazepines to seizure termination (de Jong 2003). Importantly, if convulsive activity stops, it may represent nerve agent-induced paralysis rather than termination of seizure activity, and EEG monitoring is required (Hostege et al. 1997). This project develops a first-responder EEG device for seizure management in the event of a nerve gas attack. A modified version of Persyst Reveal software will be used to solve the steady-state seizure detection problem. A wireless EEG amplifier will be developed by the Bio-Signal Group. The computing platform will be based on an off-the-shelf Pocket PC. Our goal is to make the device usable without prior instruction. Mass casualties are expected at the scene of a nerve gas attack. The proposed device should greatly reduce the neurological complications - including irreversible brain damage and death - due to prolonged seizures, which might otherwise go undiagnosed due to the paralytic effects of nerve gas agents.