A first-responder EEG device for seizure management in a nerve gas attack

描述(申请人提供)：神经毒气毒剂被许多人视为穷人的原子弹。正如1995年3月东京地铁袭击事件所表明的那样，它们可以被用来在人口稠密、空间狭小的空间造成大规模伤亡。医疗管理主要包括将病人转移到露天空间。使用阿托品，使用苯二氮卓类药物滴定惊厥以终止癫痫发作(De Jong 2003)。重要的是，如果痉挛活动停止，可能代表神经毒剂引起的瘫痪，而不是癫痫活动的终止，需要进行脑电监测(Hostege等人。1997年)。该项目开发了一种用于在神经毒气袭击事件中进行癫痫发作管理的第一反应EEG设备。PerSyst Display软件的一个修改版本将用于解决稳态癫痫发作检测问题。生物信号集团将开发一种无线脑电放大器。计算平台将基于现成的Pocket PC。我们的目标是在没有事先指示的情况下使设备可用。神经毒气袭击现场预计会有大量人员伤亡。拟议的设备应该会大大减少由于长期癫痫发作而导致的神经并发症--包括不可逆转的脑损伤和死亡--否则可能会因为神经毒气的麻痹效应而无法诊断。

DESCRIPTION (provided by applicant): Nerve gas agents are seen by many as the poor man's atom bomb. As demonstrated in the March 1995 Tokyo subway attack, they can be used to inflict mass casualties in densely populated, confined air spaces. Medical management consists primarily of removing patients to an open air space. Atropine is administered and convulsions are titrated with benzodiazepines to seizure termination (de Jong 2003). Importantly, if convulsive activity stops, it may represent nerve agent-induced paralysis rather than termination of seizure activity, and EEG monitoring is required (Hostege et al. 1997). This project develops a first-responder EEG device for seizure management in the event of a nerve gas attack. A modified version of Persyst Reveal software will be used to solve the steady-state seizure detection problem. A wireless EEG amplifier will be developed by the Bio-Signal Group. The computing platform will be based on an off-the-shelf Pocket PC. Our goal is to make the device usable without prior instruction. Mass casualties are expected at the scene of a nerve gas attack. The proposed device should greatly reduce the neurological complications - including irreversible brain damage and death - due to prolonged seizures, which might otherwise go undiagnosed due to the paralytic effects of nerve gas agents.