A geometric framework approach to understand multi-metal toxicity on individual organisms to evaluate relative risks and benefits of pollution and mit

一种几何框架方法，用于了解多金属对个体生物体的毒性，以评估污染和减排的相对风险和效益

• 批准号: 2881375
• 金额: --
• 依托单位: University of Sheffield
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2881375
• 关键词: geometric; framework; approach; understand; multi

Environmental pollution with metals is not exclusive to heavy metals but includes metals essential forlife. Organisms have adapted to harvest these often-scarce metals and use them in essential cellularmachinery such as superoxide dismutase (e.g. copper) and components of photosynthesis (e.g. iron,manganese and copper). Currently, we have a reasonable understanding of the individual toxicitylevels of metals to overall health and organismal fitness. We are lacking a perspective on the levels oftoxicity and/or benefit to organisms with different essential metal metallobiology and how thesemetals may influence cellular handling to cause interactions leading to unexpected effects inmixtures. Importantly there are examples in the literature that suggest strong interdependency ofessential metals and with other elements, both lowering and heightening toxicity thresholds.

金属对环境的污染不仅限于重金属，还包括生命所必需的金属。生物体已经适应了收获这些通常稀缺的金属，并将其用于基本的细胞机器，如超氧化物歧化酶（如铜）和光合作用的成分（如铁，锰和铜）。目前，我们对金属对整体健康和生物体健康的个体毒性水平有了合理的了解。我们缺乏一个观点的毒性水平和/或受益的有机体与不同的基本金属金属生物学和这些金属如何可能影响细胞处理，导致相互作用，导致意外的影响混合物。重要的是，文献中有例子表明，必需金属和其他元素之间存在很强的相互依赖性，既降低又提高了毒性阈值。